Yes, it can drop significantly in any kidney patient, especially ESRD. You just arent producing enough RBC (red blood cells) because you have no kidney function. It is something that has to be monitored all the time. If your HGB is low, have them check your iron levels too. If you got to take EPO shots, be sure your iron levels are up to snuff too, cause iron helps the cells to build. You may need IV iron iffusions also.
Make sure they check your iron too, especially if they prescribe EPO shots. When J was in-center, his always seemed to drop significantly, but I don't recall it ever happened after surgery. But then again, he had blood transfusions too.
God Bless,
lmunchkin