PCORI Offers Up to $90 Million in Funding in Fourth Call for Pragmatic Clinical Study ProposalsFunding Announcement Includes Eight New Topic Areas of Interest
April 6, 2015
For Immediate Release
Patient-Centered Outcomes Research Institute
WASHINGTON, DC (April 6, 2015) — The Patient-Centered Outcomes Research Institute (PCORI) today issued the latest funding announcement under its Pragmatic Clinical Studies initiative, offering up to $90 million in support for projects evaluating the effectiveness of different care options in “real-world” settings.
PCORI will provide up to $10 million in direct costs for studies lasting up to five years through this funding opportunity, the fourth offered through this initiative.
The initiative’s aim is to support large patient-centered studies that can address information gaps on health problems that place heavy burdens on patients, families, and the healthcare system. These projects are designed to produce evidence generally applicable to a wide range of patients’ needs and clinical settings and to answer critical comparative clinical effectiveness questions faced by patients and clinicians.
Unlike studies that take place with highly selected populations in specialized research centers, pragmatic studies are designed to evaluate the effectiveness of healthcare options in “real-world” practice settings, such as a typical hospital or clinic. They also tend to have broader inclusion criteria governing who can participate, so their results can be more generally applicable to a greater variety of patients with different circumstances and situations.
In issuing these funding announcements, PCORI identifies a number of research topics of particular interest, including critical questions identified by its multi-stakeholder advisory panels as well as the Institute of Medicine and the Agency for Healthcare Research and Quality. The new funding announcement includes eight such high-impact topics recommended by PCORI’s advisory panels. They focus on the effectiveness of:
… comprehensive services to support infants and their families after they are discharged from neonatal intensive care.
… multidisciplinary rehabilitation programs for managing moderate to severe traumatic brain injury in adults.
… alternative models of coordinated pain management in treating chronic, nonspecific musculoskeletal pain.
… the care provided in dental offices compared to various alternative delivery models in preventing cavities in children in medically underserved areas.
… various strategies aimed at integrating pharmacists or pharmacy services into patient care.
… evidence-based screening and primary prevention approaches at minimizing suicidality among adolescents.
… multi-component systems interventions, such as various perinatal care approaches, to improve outcomes for babies and mothers at risk for health disparities.
… clinical interventions to reduce leg and foot amputations related to diabetes among racial/ethnic minorities and low-income populations.
PCORI awarded $64.1 million in February to fund the first five studies selected through this initiative and its Board of Governors will consider another slate of potential awards at its meeting on Tuesday, April 21.
Interested applicants must submit Letters of Intent (LOIs) by no later than 5 p.m. ET on Friday, May 1. LOIs are competitive, meaning they will be screened for their responsiveness and fit to the initiative’s goals. PCORI will notify those invited to submit full applications by Friday, June 5. Other key dates and details can be found in the funding announcement.
The new funding announcement includes an array of resources designed to help research teams submit responsive proposals. In addition, PCORI staff will answer potential applicants’ questions during an informational “town hall” webinar on Tuesday, April 14.
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About PCORI
The Patient-Centered Outcomes Research Institute (PCORI) is an independent, non-profit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers and clinicians with the evidence-based information needed to make better-informed healthcare decisions. PCORI is committed to continuously seeking input from a broad range of stakeholders to guide its work.
http://www.pcori.org/content/pcori-offers-90-million-funding-fourth-call-pragmatic-clinical-study-proposals