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Author Topic: Erythropoietyn (Epo) stimulation ?  (Read 3148 times)
kristina
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« on: September 11, 2014, 02:58:43 AM »



I may or may not have mentioned before that I suffered a severe problem earlier in the year, which had all the symptoms of kidney stones
(which was probably caused by long term prescribed high doses of regular calcium intake).
This affected my kidneys badly and I became severely anaemic and needed immediate treatment (no dialysis yet), i.e. Epo injections and an iron infusion.
My Creatinine and Urea rose alarmingly and my Potassium dropped...
Over the last six months I have recovered (without needing dialysis) and my Potassium and Sodium are back under control with my strict vegetarian diet
and my Creatinine and Urea have come down considerably, such that Dialysis is not required.

It is interesting that at this point my kidneys struggle to produce enough of the hormone called “Erythropoietyn” (Epo)
which causes my haemoglobin to keep reducing after it has been “pumped up”.
So my question is: How could I naturally stimulate the production of Erythropoietyn (Epo) so I can avoid giving myself further Epo-injections once every week?

My kidneys seem to keep still fighting to keep pre-dialysis, as my blood levels record, but I cannot yet get back the control of the Erythropoietyn (Epo) production.
I am aware that I may ask for the impossible but that is what I always aim for...
Does anyone have any thoughts or ideas on how to stimulate the Erythroietyn (Epo) production naturally, perhaps with a certain ingredients in the diet?
Thanks from Kristina.
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Bach was no pioneer; his style was not influenced by any past or contemporary century.
  He was completion and fulfillment in itself, like a meteor which follows its own path.
                                        -   Robert Schumann  -

                                          ...  Oportet Vivere ...
obsidianom
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« Reply #1 on: September 11, 2014, 01:10:53 PM »



I may or may not have mentioned before that I suffered a severe problem earlier in the year, which had all the symptoms of kidney stones
(which was probably caused by long term prescribed high doses of regular calcium intake).
This affected my kidneys badly and I became severely anaemic and needed immediate treatment (no dialysis yet), i.e. Epo injections and an iron infusion.
My Creatinine and Urea rose alarmingly and my Potassium dropped...
Over the last six months I have recovered (without needing dialysis) and my Potassium and Sodium are back under control with my strict vegetarian diet
and my Creatinine and Urea have come down considerably, such that Dialysis is not required.

It is interesting that at this point my kidneys struggle to produce enough of the hormone called “Erythropoietyn” (Epo)
which causes my haemoglobin to keep reducing after it has been “pumped up”.
So my question is: How could I naturally stimulate the production of Erythropoietyn (Epo) so I can avoid giving myself further Epo-injections once every week?

My kidneys seem to keep still fighting to keep pre-dialysis, as my blood levels record, but I cannot yet get back the control of the Erythropoietyn (Epo) production.
I am aware that I may ask for the impossible but that is what I always aim for...
Does anyone have any thoughts or ideas on how to stimulate the Erythroietyn (Epo) production naturally, perhaps with a certain ingredients in the diet?
Thanks from Kristina.
In reality ther isnt any way to do it. The kidneys produce EPO hormone naturally and when they lose the ability its generally over . Thank goodness we have artificial EPO as in the old days before it we had to give blood transfusions for the severe anemia that resulted. Any gimic out there for"natural EPO " is not going to change this. If someone could do it , they would be a billionare.
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My wife is the most important person in my life. Dialysis is an honor to do for her.
NxStage since June 2012 .
When not doing dialysis I am a physician ,for over 25 years now(not a nephrologist)

Any posting here should be used for informational purposes only . Talk to your own doctor about treatment decisions.
Simon Dog
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« Reply #2 on: September 11, 2014, 01:21:40 PM »

Any gimic out there for"natural EPO " is not going to change this. If someone could do it , they would be a billionare.
There you go, inserting relevant facts into the discussion.

Thanks for your service to the forum.
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kristina
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« Reply #3 on: September 12, 2014, 06:04:06 AM »

Thank you obsidianom,
I was just hoping there may be a way to stimulate the natural production of EPO, or the beginnings of something developing in that direction, that may help.
I wasn’t looking for a gimmick, I was interested to find a stimulant, because we know there are many stimulants, natural and pharmaceutical,
that stimulate to varying degrees, according to strengths and how long one takes it, which effect some change to our body.

It is in this respect that I put the question. But, it may be there is nothing at this point to effect change with this very specific action of the kidneys.

Thank you Simon, for pointing out the great help we receive from obsidianom. I agree with you wholeheartedly.

Many thanks again from Kristina.
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Bach was no pioneer; his style was not influenced by any past or contemporary century.
  He was completion and fulfillment in itself, like a meteor which follows its own path.
                                        -   Robert Schumann  -

                                          ...  Oportet Vivere ...
obsidianom
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« Reply #4 on: September 12, 2014, 08:50:32 AM »

The reason you cant artificially stimulate Erythropoetin(EPO) from the kidneys is that in kidney disease the cells that secrete EPO are dying off and it is not a lack of stimulation . You cant stimulate dying cells to work. The body does try to stimulate EPO naturally through anemic hypoxia( low oxygen) but the ability to respond to the stimulus is no longer there as it dies. 
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My wife is the most important person in my life. Dialysis is an honor to do for her.
NxStage since June 2012 .
When not doing dialysis I am a physician ,for over 25 years now(not a nephrologist)

Any posting here should be used for informational purposes only . Talk to your own doctor about treatment decisions.
kristina
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Posts: 5530


« Reply #5 on: September 12, 2014, 12:48:19 PM »


Thank you very much for the more detailed explanation, obsidianom.
it is very much appreciated.

Many thanks from Kristina.
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Bach was no pioneer; his style was not influenced by any past or contemporary century.
  He was completion and fulfillment in itself, like a meteor which follows its own path.
                                        -   Robert Schumann  -

                                          ...  Oportet Vivere ...
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