I do not believe that D leeches out sensipar. What I do know is that it can react with some things, specially calcitricol and I was advised to NOT take them together as the sensipar would not be so effective, so I took the cal at lunchtime, and the sensipar in the evening - sometimes I took it with the meal and my other meds, but I generally tried to take it later so binders or whatever would be done with (not that I thought there was a reaction, but just to keep it kind of seperate).