The American Journal of the Medical Sciences:
POST AUTHOR CORRECTIONS, 15 March 2010
doi: 10.1097/MAJ.0b013e3181d8b6ff
Clinical Investigation: PDF Only
Exploring the Effect of Parathyroidectomy for Tertiary Hyperparathyroidism After Kidney TransplantationKandil, Emad MD; Florman, Sandy MD; Alabbas, Haythem MD; Abdullah, Obai MD; McGee, Jennifer MD; Noureldine, Salem MD; Slakey, Douglas MD; Zhang, Rubin MD, FASN
Published Ahead-of-Print
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Abstract
Tertiary hyperparathyroidism (tHPT) usually regresses after renal transplantation. Persistent tHPT after successful renal transplantation may require parathyroidectomy (PTX). PTX has been reported to be associated with deterioration of renal function and graft survival. We retrospectively analyzed 794 kidney transplants performed at our center with at least 3 years of follow-up to examine the effect of PTX on the renal function and graft survival. Forty-nine of the 794 renal transplant recipients were diagnosed with hyperparathyroidism (HPT) before transplant. Nineteen of 49 patients had persistent tHPT and underwent PTX after kidney transplants. Patients with HPT and non-HPT had similar 3-year graft survival (88% versus 84%, P = 0.51). PTX was associated with a decreased glomerular filtration rate at 3 years (44.7 +/- 20.0 versus 57.7 +/- 23.7 mL/min, P = 0.04); however, there was no statistical difference in the 3-year graft survival (71% versus 88%, P = 0.06). PTX in renal transplant recipients seems to be a safe and effective therapy for persistent tHPT. PTX may be associated with worsening glomerular filtration rate, but it may not be associated with significantly decreased long-term graft survival.
http://journals.lww.com/amjmedsci/Abstract/publishahead/Exploring_the_Effect_of_Parathyroidectomy_for.99786.aspx
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