the use of bisphosphonate on calciphilaxis

[Wiwieh Ruslim]

Hello I'm from Indonesia. Calciphylaxis (calcification in the blood vessel) is a very rare and fatal desease in here. My mother is 74 years old, and she's diabetic and already takes HD 3x a week. The doctors said that her heart function is only 38% left. Now she has ulcers on both legs and beginning to spread. She also has calciphylaxis. What I want to know is what will happened if I give her Bisphosphonate / Pamidronate 30mg/10ml injections to treat the calciphylaxis according to her conditions earlier. What's the side effects? Please any informations will be very helpful to us.
Thank you.

[okarol]

I found this about :Bisphosphonate / Pamidronate (you may have already seen this but I am copying it in case you haven't.)

Successful treatment of calciphylaxis with pamidronate. http://ndt.oxfordjournals.org/cgi/content/full/19/8/2130

Also found this:
MAYO CLINIC
Calciphylaxis Treatment
Calciphylaxis is first treated with conservative therapy such as changing diet, medications and the dialysis prescription (for patients already on dialysis). Doctors evaluate and eliminate potential trigger factors such as corticosteroids or use of iron and calcium supplements and work to bring calcium and phosphate to normal levels. This may involve using a medication (Cinacalcet) or surgery to better regulate PTH hormone, a hormone secreted by the parathyroid glands which regulates the body's use of calcium and phosphorus. Doctors often refer patients to a dietitian familiar with the dietary needs and restrictions of patients with kidney disease.

A new treatment, tissue plasminogen activator (tPA, alteplase), has shown promise in preventing major ulceration and reducing patient mortality. This medication (also used in treating heart attacks) can dissolve blood clots in skin blood vessels affected by calciphylaxis.

Other treatments include:

Low-calcium bath dialysis
Medical or surgical treatment to reduce the concentration of parathyroid hormone
Antibiotic treatment
Pain medication
Intravenous vitamin D (in special circumstances)
Hyperbaric oxygen treatments
Blood thinning medications
Surgery
For patients with clearcut evidence of overactive parathyroid glands, surgery to remove all or part of the parathyroid glands may be necessary — although this does not guarantee that hyperparathyroidism won't recur. Surgery may also be needed to remove dead or contaminated tissue to avoid infection or amputation.

http://www.mayoclinic.org/calciphylaxis/treatment.html