I Hate Dialysis Message Board

Dialysis Discussion => Dialysis: General Discussion => Topic started by: Joe Paul on December 18, 2007, 02:52:28 AM

Title: Reusable dialyzers
Post by: Joe Paul on December 18, 2007, 02:52:28 AM
I am curious, those of you in center, do you pay attention to how many times your dializers are reused? Before the new Neph took over at my center, the max times reused was 20. Now they go up to 35. I complain because of the color of the dializer at the return end, its black and looks disgusting, but the bio-tech tells me its an optical illusion, sort of like fiber optics. I guess it is doing its job, my clearances have been in the 70's and according to the tag, the dializer passes testing. I just don't feel comfortable seeing all that "gunk".
Title: Re: Reusable dializers
Post by: BigSky on December 18, 2007, 03:21:02 PM
Tell them you only want to reuse it twenty times.

My understanding is its up to the patient, not the center.
Title: Re: Reusable dializers
Post by: Ang on December 18, 2007, 04:27:25 PM
sorry  but is'nt  re  using  dialysers  unsanitary  unhealthy  etc  etc. :urcrazy; at my  unit  in  :ausflag;  they  use  new  dialysers  for  each  person  each  treatment.
 i  sort  of  figured  it  was  the  same  all  over  the  world









EDITED: Fixed smiley tag error- kitkatz, moderator
Title: Re: Reusable dializers
Post by: cris on December 18, 2007, 04:30:28 PM
Over in the Phils, dialyzers are being re-used up to 10x maximum or it is up to the patient to change it earlier than the 10th time. This is expensive.
Title: Re: Reusable dializers
Post by: Adam_W on December 18, 2007, 08:00:12 PM
Ewww! It's black on the end and they are making you reuse it? That's just disgusting. Like everyone else has said, tell them you only want it reused however many times YOU feel comfortable with. It's your health and your life they're messing with here. I'm personally not comfortable with reusing dialyzers period, although I've never actually reused one.

Adam
Title: Re: Reusable dializers
Post by: kitkatz on December 18, 2007, 09:28:19 PM
I cannot do reuse. I am allergic to the fibers in those dialyzers.  I am expensive patient!
Title: Re: Reusable dializers
Post by: thegrammalady on December 19, 2007, 01:59:01 AM
sorry  but is'nt  re  using  dialysers  unsanitary  unhealthy  etc  etc. :urcrazy; at my  unit  in  :ausflag;  they  use  new  dialysers  for  each  person  each  treatment.
 i  sort  of  figured  it  was  the  same  all  over  the  world


EDITED: Fixed smiley tag error- kitkatz, moderator


reuseable dialyzers are cleaned between each use and only used for one patient each.  that being said, my center stopped using them about 9 months ago
Title: Re: Reusable dializers
Post by: KR Cincy on December 19, 2007, 07:26:37 AM
It's one more thing I like about home hemo with the NxStage...a clean new kidney each and every treatment!
Title: Re: Reusable dializers
Post by: Bajanne on December 19, 2007, 07:39:28 AM
They don't reuse at my centre, but I am told that at the centre in the hospital in my home country they do.  In fact, one of my nurses here told me that she did a course at my country's hospital on reusing. They don't reuse at the private centre, only the hospital.  I am told that it is fine, but so far I haven't had to deal with it.  Hearing about the black stuff is not at all pleasant.
Title: Re: Reusable dializers
Post by: Joe Paul on December 19, 2007, 07:57:18 AM
It's one more thing I like about home hemo with the NxStage...a clean new kidney each and every treatment!
Nxstage would be great IF your insurance pays for it. I would have to change insurance and doctors to get it, been there tried that.
Title: Re: Reusable dializers
Post by: glitter on December 19, 2007, 08:42:10 AM
my husbands center reuses up to 28 times-he has not had any problems and his clearance is good- but it is not up to him how many times. In the beginning when we objected to the policy- we were told it was there policy, if we did not like it we would have to find another center.
Title: Re: Reusable dializers
Post by: BobT1939 on December 19, 2007, 08:44:13 AM
At my center the patient has an option, reuse or not. Pros and cons are explained, then patient chooses./bobt
Title: Re: Reusable dializers
Post by: BigSky on December 19, 2007, 03:54:58 PM
How should my dialyzer look before treatment?

Your dialyzer should look clean. If your dialyzer looks clotted or dirty, speak to your dialysis care team before starting your treatment. Always
check the appearance of your dialyzer before each treatment.

 Make sure the dialyzer:

 looks clean
 has no more than a few clotted fibers
 has clean tops and bottoms that are free of all but small clots
 is not leaking
 is capped on all openings or ports
 is clearly labeled with your name.

Reuse information from :

NKF
http://www.kidney.org/atoz/pdf/dialyzer_reuse.pdf
Title: Re: Reusable dializers
Post by: plugger on December 20, 2007, 11:11:34 AM
I've read studies about reuse and it got me real concerned; not only is the performance of the dialyzer degraded, but there is usually remnants of the cleaning fluid left in the dialyzer - not at all good for a person's health.  My daughter was on dialysis years ago and when I saw those studies, I told the doctor I wanted her off.  He put up a little fight, but did as I asked after he saw how worked up I was about it.

I recall I had to sign some piece of paper allowing reuse for her when she first started, but I understand it isn't worth the paper it is written on since a person doesn't know what they are signing and it is usually signed during a stressful time.
Title: Re: Reusable dializers
Post by: plugger on December 20, 2007, 11:14:25 AM
You might be told a dialyzer is fine since they use these strips to test them, however the strips only test for less than a small amount of cleaning fluid - not the absence of cleaning fluid.
Title: Re: Reusable dializers
Post by: willieandwinnie on December 20, 2007, 12:13:24 PM
When my husband started in center, they used resuse and he kept having a skin reaction. The neph stop his reuse and the skin problem stopped. The nurses always said they recired them a lot, but I never believed them. Lucky when we started home hemo it wasn't an issue and thank God, he now has a transplant. You guys are reminding me of exactly why I hated going to the clinic.  >:D
Title: Re: Reusable dializers
Post by: Joe Paul on December 20, 2007, 12:18:54 PM
Well, after reading some of the replies, I am going to ask to be switched to the one time use dialyzer. Thanks to all those who replied  :thumbup;
Title: Re: Reusable dializers
Post by: charee on December 20, 2007, 03:31:52 PM
Here in Aus I have never heard of reusing dializers, sounds yuk to me but i suppose it saves them money.
Title: Re: Reusable dializers
Post by: BigSky on December 20, 2007, 04:35:39 PM
I've read studies about reuse and it got me real concerned; not only is the performance of the dialyzer degraded, but there is usually remnants of the cleaning fluid left in the dialyzer - not at all good for a person's health.  My daughter was on dialysis years ago and when I saw those studies, I told the doctor I wanted her off.  He put up a little fight, but did as I asked after he saw how worked up I was about it.

I recall I had to sign some piece of paper allowing reuse for her when she first started, but I understand it isn't worth the paper it is written on since a person doesn't know what they are signing and it is usually signed during a stressful time.


Those studies would be outdated now.

They did have a problem at one time.  It was attributed to a combination of what the dialyzers were made of and the cleaning agent used I believe.  Todays dialyzers are made differently and so far studies show there is no difference in mortality rates and very little if any in performance.
Title: Re: Reusable dializers
Post by: plugger on December 20, 2007, 06:26:43 PM
I haven't seen anything that would lead me to believe reuse is a good thing, so if you could back that up I would like to see it.  I did a search on my computer and I did find some things I had so we can compare notes.
Title: Re: Reusable dializers
Post by: plugger on December 20, 2007, 06:28:11 PM
Why Fresenius Medical Care Decided Not to Reuse Dialyzers
By J. Michael Lazarus, MD


In the early 1970s, I joined with the late Dr. Peter Lundin in a pro and con debate on the use of reused dialyzers which was printed in this magazine. Peter argued against reuse of dialyzers and I supported reuse. My decision to recommend reused dialyzers for my patients (and to argue for that approach) was based on the fact that cuprophane membranes were being used at that time and there was a very significant occurrence of "first use" syndrome related to the exposure of patients to new cuprophane membranes. I also argued at the time, that dialyzers were expensive and reuse would allow dialysis facilities to use savings in other ways in the delivery of care for patients. My willingness to ask my patients to be dialyzed on reused dialyzers was based on my commitment that dialyzers would be properly processed and would be as safe as a new dialyzer. The American Association of Medical Instrumentation (AAMI) subsequently developed policies and procedures to assure safe dialyzer reuse.



The vast majority of dialysis units and dialysis patients have utilized reused dialyzers over the ensuing years. With the availability of more biocompatible synthetic membranes in the late 1980s and early 1990s, concerns about "first use" syndrome and any medical advantage, however small it may have been, disappeared. However, synthetic membranes, which were developed in Europe and shipped to the United States, were extremely expensive. The only possible way to use dialyzers with synthetic membranes was to continue with reuse. In the 1990s, there were several studies with large retrospective analyses, which suggested that either reused dialyzers or certain chemicals used in the reuse process were linked to an increased mortality in those facilities in which reuse was utilized. This topic and the analyses have been hotly debated for a number of years with no clear resolution.


In 1995, Fresenius USA made a decision to bring the manufacture of dialyzers to the United States where they could be produced in greater quantities at a lower cost. Over the subsequent five years, this has been accomplished. Based on this capability, Fresenius Medical Care (FMC) recently made the decision to abandon reuse of dialyzers over the next two years. The two-year period is necessary because it will take that long to ramp up production of polysulfone dialyzers to an adequate quantity to supply all FMC facilities as well as Fresenius' external customers. We have come to the conclusion that the cost of reuse related to the cost of personnel, reuse materials, and compliance with federal and state regulatory issues regarding reuse, is now equal to or more than the cost of a new polysulfone dialyzer.



We believe that our conversion to non-reuse will allow staff to dedicate more time and attention to other patient care issues. We believe there is no disadvantage whatsoever to patients receiving new kidneys utilizing polysulfone membranes. For those physicians and patients who are comfortable and confident with reuse, we will allow them to continue to utilize reused dialyzers if that is their wish. For those who choose otherwise, we now have the ability to provide high quality single-use biocompatible dialyzers.



I wish my good friend, Peter Lundin, were here to see that we have arrived at an approach which he and I would agree is in the best interest of our patients and the program at-large.




J. Michael Lazarus, MD is the Medical Director and Senior Vice President of Clinical Quality for Fresenius Medical Care North America (FMCNA). Dr. Lazarus is Vice Chairman of the Board of Directors of Renaissance Health Care, Inc., and is on the Board of Directors of Optimal Health Care, Inc. Both are FMCNA-affiliated companies. He is an Associate Professor of Medicine at Harvard Medical School.

This article originally appeared in the January 2002 issue of aakpRENALIFE, Vol. 17, No. 4.
Title: Re: Reusable dializers
Post by: plugger on December 20, 2007, 06:29:57 PM

http://sprojects.mmi.mcgill.ca/heart/carecharsum3.html
Pyrogenic or endotoxic reactions reported in the reuse of hemodialysers are associated with a high number of reuses and use of manual reprocessing systems. Despite earlier reports of decreased mortality with reprocessed dialysers, a major U.S. study has found a higher incidence of mortality in free-standing dialysis clinics which reprocess with Renalin. Reuse of dialysers prevents the "first- use syndrome" seen with new dialysers. No longer is this an argument to favor reuse now that all new units are degassed and rinsed prior to use. A controversial result of dialyser reuse is the development of anti-N antibodies in patients being dialysed by units reprocessed with formaldehyde. These antibodies are thought to cause early graft failure in organ transplants, although other researchers believe that their significance is unknown.
Title: Re: Reusable dializers
Post by: plugger on December 20, 2007, 07:01:26 PM
(I did some googling and found the following that is more recent.  It seems the author worried about a single use dialyzer having manufacturing chemicals - but I seem to recall a couple of bags of saline run through a dialyzer should take care of that problem)

Although single dialyzer use and reuse by chemical reprocessing are both associated with some complications, there is no definitive advantage to either in this respect. Some complications occur mainly at the first use of a dialyzer: a new cellophane or cuprophane membrane may activate the complement system, or a noxious agent may be introduced to the dialyzer during production or generated during storage. These agents may not be completely removed during the routine rinsing procedure. The reuse of dialyzers is associated with environmental contamination, allergic reactions, residual chemical infusion (rebound release), inadequate concentration of disinfectants, and pyrogen reactions. Bleach used during reprocessing causes a progressive increase in dialyzer permeability to larger molecules, including albumin. Reprocessing methods without the use of bleach are associated with progressive decreases in membrane permeability, particularly to larger molecules.
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1525-139X.2006.00158.x?journalCode=sdi

Zbylut J. Twardowski (2006)
Dialyzer Reuse—Part II: Advantages and Disadvantages
Seminars In Dialysis 19 (3), 217–226.
doi:10.1111/j.1525-139X.2006.00158.x
Title: Re: Reusable dializers
Post by: BigSky on December 20, 2007, 07:27:38 PM
I haven't seen anything that would lead me to believe reuse is a good thing, so if you could back that up I would like to see it.  I did a search on my computer and I did find some things I had so we can compare notes.

http://www.aakp.org/aakp-library/Reuse-Hemodialyzers/index.cfm





Title: Re: Reusable dializers
Post by: Joe Paul on December 21, 2007, 08:26:15 AM
I requested to use non-reusable dializers, but was shot down. They want me to try another re-usable, and when I feel its too dirty looking, will get another re-usable. We will see how this works out though, maybe Santa will bail me out and get me the transplants I asked for  :santahat;
Title: Re: Reusable dializers
Post by: stauffenberg on December 21, 2007, 09:33:39 AM
The significant point is that even at periods when the technology was such that re-use of dialyzers was known to be toxic for the patients, American dialysis providers persisted in re-using them, since this was yet another way to increase their profit margin within the fixed reimbursement for dialysis treatment allowed them by Medicare.  This willingness to harm patients physically in order to increase profits represents greed bordering on insanity, which in America is called 'free enterprize.'  In other countries, when re-use was known to be toxic, there was no re-use allowed, since dialysis was provided by the government solely to serve the health of the population, not to make profits for anyone.
Title: Re: Reusable dializers
Post by: boxman55 on December 21, 2007, 05:04:41 PM
I double checked with my clinic and they said absolutely not they would never reuse...Boxman
Title: Re: Reusable dializers
Post by: plugger on December 22, 2007, 06:59:08 AM
BigSky,

I read over your article from the AAKP and I'm not seeing much new.  I also have problems with an article when they talk about how a plasma protein from a patient's blood makes the dialyzer less likely to activate the "complement system"; I have to wonder if the author didn't get the memo about the new dialyzers being more biocompatible - also a flaw with that 3rd article I posted.

And correct me if I'm wrong, but doesn't the AAKP get a lot of it's funding from the dialysis companies?
Title: Re: Reusable dializers
Post by: BigSky on December 22, 2007, 02:28:20 PM
Not sure funding is going to play into AAKP opinion as they probably are funded by manufactures of supplies also.
   
However with Fresenius  it is in their interest to push new dialyzers over resuse.  They are a huge supplier of product and it will definitely benefit their bottom line by them now pushing the industry to go to new vs reuse.  Yes it seems ideal to go with new but when its a major supplier pushing the objective some huge doubts are raised as to their motive.

Fact is they force,  dialysis clinics to buy their dialyzers  if they need any product from them, such as bicarbonate.

A key sentence of their statement was this.

"We believe there is no disadvantage whatsoever to patients receiving new kidneys utilizing polysulfone membranes."

Those certainly are not the words one would use to tout new dialyzers vs reuse if in fact reuse was no good and new was so much better.

Title: Re: Reusable dializers
Post by: plugger on December 22, 2007, 05:03:57 PM
Fresenius spent a lot of years doing reuse and might want to be careful not to knock it too much.  When my daughter was in a Fresenius clinic they used formaldehyde for reuse which concerns me after finding this:


"Handbook of Dialysis" by John T Daugirdas, Peter Gerard Blake, Todd S. Ing
published 2006 page 197

Anti-N antibodies: These can be produced when residual dialyzer formaldehyde levels are high and
have been associated with hemolysis and with early transplant failure; one group has reported their
development even when dialyzers were rinsed to the point that effluent formaldehyde levels were
always below 2-3 ppm (Vanholder et al., 1988).
Title: Re: Reusable dializers
Post by: plugger on December 23, 2007, 06:36:37 AM
Joe Paul,

I emailed a couple of friends about your predicament with reuse and hope to get a response to see if anything can be done.

And since I haven't seen anything yet to change my mind about the issue of reuse, I'm going to post a link to the old DialysisEthics site that has numerous studies done on reuse - I'm not seeing anything to invalidate them:
http://www.dialysisethics.org/forum/viewtopic.php?t=488

Title: Re: Reusable dializers
Post by: BigSky on December 23, 2007, 08:25:03 AM
Joe Paul,

I emailed a couple of friends about your predicament with reuse and hope to get a response to see if anything can be done.

And since I haven't seen anything yet to change my mind about the issue of reuse, I'm going to post a link to the old DialysisEthics site that has numerous studies done on reuse - I'm not seeing anything to invalidate them:
http://www.dialysisethics.org/forum/viewtopic.php?t=488

They were never valid in the first place.  They are limited in design because they are not prospective, randomized and controlled trials.

A more recent report than those studies, the USRDS Dialysis and Morbidity Study,  has further verified that there is no difference in mortality for reuse and single ­use dialyzers.  The fact that study is more recent would also invalidate those prior studies on the issue of reuse today.



However certain giants of the industry will push for new because it is those sales of new dialyzers to others outside their own units that will turn around and subsidizes the cost of dialyzers to their own units thus making the cost ratio that much more rosy in their marketing of the dialyzers IMO.

Regardless of that I do not see how a unit can dictate if one wanted new or reuse.  I would think the only control they have would be if they had to provide a high end dialyzer or a middle of the road new one.


Title: Re: Reusable dializers
Post by: plugger on December 26, 2007, 06:32:41 AM
Just because this study you speak of is more recent doesn't necessarily mean it invalidates everything previous.  Who funded the study, who did the study, their motivation, and their methods have to be considered.  We have two major players here: Fresenius who I will admit probably wants to sell dialyzers and DaVita who has just as strong a motivation not to buy new dialyzers.  Who to believe?  I guess I look for studies I hope are from more independent sources and make sense.  When a study starts talking about biocompatibility and protein layers in a dialyzer, that article or study is pretty quickly off my reliable list since I've heard for years the new dialyzer membranes don't have a problem with biocompatibility - I just get the feeling the author is either trying to put one over or hasn't done proper research.

Anyway, would you be able to provide a link to this USRDS study?  I might be able to find it myself, but would be helpful and faster if you had it.
Title: Re: Reusable dializers
Post by: plugger on December 26, 2007, 06:52:26 AM

Not sure funding is going to play into AAKP opinion as they probably are funded by manufactures of supplies also.
   

And these suppliers aren't going to tick off a big customer like DaVita - so the AAKP opinion is still suspect in my book.
Title: Re: Reusable dializers
Post by: BigSky on December 26, 2007, 08:31:41 AM
Just because this study you speak of is more recent doesn't necessarily mean it invalidates everything previous.  Who funded the study, who did the study, their motivation, and their methods have to be considered.  We have two major players here: Fresenius who I will admit probably wants to sell dialyzers and DaVita who has just as strong a motivation not to buy new dialyzers.  Who to believe?  I guess I look for studies I hope are from more independent sources and make sense.  When a study starts talking about biocompatibility and protein layers in a dialyzer, that article or study is pretty quickly off my reliable list since I've heard for years the new dialyzer membranes don't have a problem with biocompatibility - I just get the feeling the author is either trying to put one over or hasn't done proper research.

Anyway, would you be able to provide a link to this USRDS study?  I might be able to find it myself, but would be helpful and faster if you had it.


On its own it would not invalidate them.   However they were not valid in the first place.  Reason being they were not scientific in nature.  They were  not prospective, randomized and controlled trials.   

I mean I could make the claim that all people who eat carrots die.  Therefore no one should eat carrots if they do not want to die.  All evidence points to the fact that all people who eat carrots die so does that make the conclusion right?  No, because it was not a controlled trial. 


I certainly agree that at one point there was a problem with resuse.  However it was a variety of factors that led to an increased death rate for those few years and once those problems were recognized and corrected those problems disappeared. 

I haven't bothered to look at recent stats, but as of 1997 most of the world practices reuse.  There were a few that quit reuse but that stemmed from other issues not related to reuse itself.  Such as France where there was a huge scandal with blood banks etc.  I am not sure but even to this day in France reuse is still not banned but however due to those scandals they still haven't gone back into reuse.


Also of note is that Fresenius does not make the claim that new is better than reuse.  They push new but do not come straight out with that claim.  That does speak volumes in todays business world.  If one is trying to change the way the market operates such as going to new use all the time, that would be something they would do if it was true just to change the market share to support them. 

Another case is it has been well over 6 months and Fresenius still hasn't emailed me the stats on their dialyzers.  I would think a company pushing new would be glad to be transparent and release this information.  When one leaves it clouded in mystery it severaly raises questions.  Currently our unit is forced to purchase some Fresenius dialyzers.  However most chose to use Gambro reuse, of which Gambro OPENLY publishes its stats and efficiency of its dialyzers (both new and resue) on the net. 

It is that transparency that tells of a companies belief in their product.  It is very troubling to me that Fresenius or NxStage are lacking in that particular transparency. 



And these suppliers aren't going to tick off a big customer like DaVita - so the AAKP opinion is still suspect in my book.

Yet doesnt Fresenius donate to the AAKP also?

My understanding from AAKP is that they receive funding from all sectors of the Industry.





Title: Re: Reusable dializers
Post by: plugger on December 26, 2007, 03:10:24 PM
I imagine Fresenius does give to the AAKP and I imagine they aren't going to go as far as saying reuse is a terrible, horrible thing because someone like me would find a lawyer and slap them with a lawsuit so fast it would make their heads spin - I feel even back in 2000 they knew this was a dangerous practice, yet they still fought me when I stopped them doing reuse on my daughter.

By the way, I still don't see this mysterious "USRDS Dialysis and Morbidity Study" you refer to.  All I'm seeing is that old AAKP article from 2002 and a lot of smoke from you - I'm sure the authors of these studies I'm pointing out would love to hear what they are doing isn't scientific.

So far besides the older studies, I've pointed out a more recent blurb from a book published in 2006.  Here is something even more recent:

"The practice of reusing dialyzers has been widespread in the United States for decades, with single use showing signs of resurgence in recent years. Reprocessing of dialyzers has traditionally been acknowledged to improve blood–membrane biocompatibility and prevent first-use syndromes. These proposed advantages of reuse have been offset by the introduction of more biocompatible membranes and favorable sterilization techniques. Moreover, reuse is associated with increased health hazard from germicide exposure and disposal. Some observational studies have also pointed to an increased mortality risk with dialyzer reuse, and the potential for legal liability is another concern. The desire to save cost is the major driving force behind the continued practice of dialyzer reuse in the United States."
http://cjasn.asnjournals.org/cgi/content/abstract/2/5/1079
August 16, 2007

You have accomplished one thing: I'm now angry again about an issue I let go dormant for years now.  I'm trying to call the one friend who just might be interested in seeing what we can do about helping someone who wants to get off reuse - stay tuned.

Title: Re: Reusable dializers
Post by: BigSky on December 26, 2007, 05:43:06 PM
So if Fresenius donates to them doesn't that invalidate your argument that the AAKP is beholden somehow to the likes of Davita?

No one said anything about Fresenius saying reuse was terrible or horrible.

The most telling thing is they are not claiming new is better, they are saying their is no DISADVANTAGE to using new.  That is not the wording one uses if new is so much better as you seem to suggest.

Yet that still doesnt address the issue of them not being transparent to their dialyzer stats.



Mortality risk by hemodialyzer reuse practice and dialyzer membrane characteristics: results from the usrds dialysis morbidity and mortality study.
Port FK, Wolfe RA, Hulbert-Shearon TE, Daugirdas JT, Agodoa LY, Jones C, Orzol SM, Held PJ.

US Renal Data System Coordinating Center, Department of Internal Medicine, University of Michigan, Ann Arbor, USA. portb@umich.edu

Hemodialyzer reuse is commonly practiced in the United States. Recent studies have raised concerns about the mortality risk associated with certain reuse practices. We evaluated adjusted mortality risk during 1- to 2-year follow-up in a representative sample of 12,791 chronic hemodialysis patients treated in 1,394 dialysis facilities from 1994 through 1995. Medical record abstraction provided data on reuse practice, use of bleach, dialyzer membrane, dialysis dose, and patient characteristics and comorbidity. Mortality risk was analyzed by bootstrapped Cox models by (1) no reuse versus reuse, (2) reuse agent, and (3) dialyzer membrane with and without the use of bleach, while considering dialysis and patient factors. The relative risk (RR) for mortality did not differ for patients in reuse versus no-reuse units (RR = 0.96; 95% confidence interval [CI], 0.86 to 1.08; P > 0.50), and similar results were found with different levels of adjustment and subgroups (RR = 1.01 to 1.05; 95% CI, lower bound > 0.90, upper bound < 1.19 each; each P > 0.40). The RR for peracetic acid mixture versus formalin varied significantly by membrane type and use of bleach during reprocessing, achieving borderline significance for synthetic membranes. Among synthetic membranes, mortality was greater with low-flux than high-flux membranes (RR = 1.24; 95% CI, 1.02 to 1.52; P = 0.04) and without than with bleach during reprocessing (RR = 1.24; 95% CI, 1.01 to 1.48; P = 0.04). Among all membranes, mortality was lowest for patients treated with high-flux synthetic membranes (RR = 0.82; 95% CI, 0.72 to 0.93; P = 0.002). Although mortality was not greater in reuse than no-reuse units overall, differences may exist in mortality risk by reuse agent. Use of high-flux synthetic membrane dialyzers was associated with lower mortality risk, particularly when exposed to bleach. Clearance of larger molecules may have a role.


Be angry all you want.  You are pushing studies that were never valid in the first place.  What am I supposed to do, sit back and let you push these invalid studies?  If one wants to reuse or not is entirely up to them IMO and no one else, but trying to justify not to on the grounds of those flawed studies is plain irresponsible IMO.  Those studies are nothing but scare tactics that have no true merit behind them.
Title: Re: Reusable dializers
Post by: plugger on January 05, 2008, 10:17:13 AM
BigSky wrote:
"So if Fresenius donates to them doesn't that invalidate your argument that the AAKP is beholden somehow to the likes of Davita?"
Hardly, with Fresenius's past they would want to stay neutral on the issue.  Suppliers aren't going to say anything because they wouldn't want to tick off a big customer like DaVita.  That leaves DaVita - with a financial incentive - to push for reuse.

BigSky wrote:
"No one said anything about Fresenius saying reuse was terrible or horrible."
No, I said it.

BigSky wrote:
"The most telling thing is they are not claiming new is better, they are saying their is no DISADVANTAGE to using new.  That is not the wording one uses if new is so much better as you seem to suggest."
Of course Fresenius isn't going to say anything about reuse being bad.  As I pointed out, they have a history with it and I imagine they don't want to be liable for what they have done in the past.

As for our dualing studies, you've got ONE that says maybe it isn't so bad - I seem to have a whole lot more that says it is bad.  I don't know, maybe we can go back and forth all day with this study said this and that study said that; but what it boils down to for me is: Do I believe they get all of the cleaning agent out of dialyzers? -no.  Do I believe reuse degrades the performance of the dialyzer? -yes.  Am I going to let a relative of mine do this practice if I can help it? - h*ll no!
Title: Re: Reusable dializers
Post by: BigSky on January 05, 2008, 11:22:18 AM

Of course Fresenius isn't going to say anything about reuse being bad.  As I pointed out, they have a history with it and I imagine they don't want to be liable for what they have done in the past.

As for our dualing studies, you've got ONE that says maybe it isn't so bad - I seem to have a whole lot more that says it is bad.  I don't know, maybe we can go back and forth all day with this study said this and that study said that; but what it boils down to for me is: Do I believe they get all of the cleaning agent out of dialyzers? -no.  Do I believe reuse degrades the performance of the dialyzer? -yes.  Am I going to let a relative of mine do this practice if I can help it? - h*ll no!


You best go back and reread what you posted because most of what you posted was abstract and opinion.  Not "a whole lot of studies" and many of those opinions took information from the same study.   In fact you are basing your opinion on a outdated study that is making its judgment on outdated methods of processing reuse dialyzers.

Do they get all cleaning agents out?  Hmm depends.  By all standards its measured in ppm (parts per million) and every test strip we use shows 0 ppm and if it does measure even 1 ppm its not used until its clear. 

Downgraded performance.   Really,  Me, I know what my Kt/V is with reuse and I know what it is with new.  Too bad you cannot say the same thing can you.  Dialyzers used for reuse have to give information to the FDA and make sure they still work within guidelines specified.  It can vary with method of cleaning solution however the majority of centers use renlin these days so any downgrade is insignificant.  The only area of downgrade would be urea removal and that is only at 1 to 2% which is insignificant. Beta2-microglobulin clearance of polysulfone dialyzers remains unchanged.

I'm sure you wouldnt let a relative use reuse because you are basing you conclusion on unscientific studies on most methods that are no longer used by well over 90% of clinics in the US.

Past and current studies show mortality rate is higher in for profit centers than there is versus non profit centers. 

So are you telling relatives not to run in for profit centers also?


Currently with FMC owning by their own accord 70% of the dialysis machine market it seems they would benefit billions if they can push new vs reuse. So it seems it will benefit FMC far more than anyone else in the industry. 



Title: Re: Reusable dializers
Post by: plugger on January 05, 2008, 01:03:51 PM
I may get back to this later, but for one thing I recall test strips measure for a minimal amount of cleaning agent - not the absence of it.  I'm standing by what I've said, but I do hope you are right - however, there is still a whole lot that says you are not.
Title: Re: Reusable dializers
Post by: Thalia on January 05, 2008, 01:12:29 PM
my Mom's center said they do not reuse dializers because it was very difficult to completely remove the cleaning agent
Title: Re: Reusable dializers
Post by: plugger on January 05, 2008, 01:30:41 PM
Yes, that's what I've heard for years now and this seems to confirm that:

"Serim Residual Formaldehyde Test Strips

    * Meets AAMI standards of 5.0-ppm (and California standards of 3.0-ppm)"
http://www.serim.com/technical_tips_dialysis.cfm

They measure for less than 5.0 or 3 ppm - apparently they may not make it all go away.
Title: Re: Reusable dializers
Post by: BigSky on January 05, 2008, 01:51:37 PM
Majority of units no longer use formaldehyde.  They use renalin of which test strips start at 1 PPM.
Title: Re: Reusable dializers
Post by: plugger on January 05, 2008, 05:06:18 PM
Haven't heard much good about renalin either.  I did find this about renalin test strips:

After effective rinsing, a test strip should
show a color intensity that is <3 ppm.
http://www.minntech.com/renal/resource/renews/ReNews_v8.pdf

Anyway, let's say for a minute the reuse procedure is so good they can get every molecule of cleaning agent out - which I seriously doubt.  You still have to trust that some under-paid person working in a back room is going to get it right every time.  I have doubts it will happen.  In fact I can recall it not happening.
Title: Re: Reusable dializers
Post by: plugger on January 05, 2008, 05:24:21 PM
Also I got a reply from a lawyer friend about reuse.  He had this to say:

"Yes, patient has right to new dialyzer, but it is up to MD as to which one.  Fresenius now has a no-reuse national policy.  I have noticed that patients who kick and scream on this matter get what they want, but are told not to discuss it with other patients."
Title: Re: Reusable dializers
Post by: BigSky on January 05, 2008, 06:59:11 PM
Well our strips test start lower than that and each color indicates a higher ppm.  I will have to read the bottle again and get each measurement.

People do have a right to use single use dialyzers.  At anytime they feel uncomfortable by all means they should do what they feel is best.  THe situtation that Joe Paul described is not normal nor is it an optical illusion.  From what he describes it violates the rules set forth on reuse IMO.

While the doctor does pick the dialyzer, I did read once that units do not have to carry single use high flux dialyzers.  They can carry lower quality cost single use.  Doctors merely make a selection from which dialyzers the units carry.

You do know those same underpaid people also do all the stuff you dont see right?  Test water, make dialysate, bleach and culture machines and equipment.  Or do you think its only the area of them cleaning dialyzers we need to worry about?

Title: Re: Reusable dializers
Post by: plugger on January 06, 2008, 06:52:25 AM
Nice to see we can agree Joe Paul has the right to single-use.  And yes, I definitely know the techs are responsible for much more; that is why I helped get a state bill for tech certification started here in Colorado - it got passed by the way.  I recall reading a lot of complaints from different states and I was amazed at all the different things that can go wrong, but I don't think we will be going back to the days when just RNs were giving the treatments anytime soon.

As you say, getting the right dialyzer can be a problem too.  I know a lady who was on dialysis 11 1/2 years and she knew what dialyzer she wanted, but the Fresenius doctor wouldn't give it to her because it wasn't Fresenius made; she wound up with one that left her feeling wiped out after treatments.  Can you tell I have trust issues with both the major companies in this?
Title: Re: Reusable dialyzers
Post by: Joe Paul on January 08, 2008, 03:32:22 AM
Thanks for all the information guys. I informed the charge nurse yesterday that I do not want to keep on using the re-usable dialyzer. After only 5 uses, the thing looked crappy again. She wrote on my chart "patient refuses recommended re-use dialyzer".
Title: Re: Reusable dialyzers
Post by: plugger on January 08, 2008, 10:55:08 AM
Great to hear!  Even if I trusted this reuse practice, something doesn't sound right.
Title: Re: Reusable dialyzers
Post by: qwerty on January 08, 2008, 11:28:37 AM
bottom line is by law everyone on treatment has the right to "refuse" re-use dialyzers. I know it's part of the consent forms we use (soon to be former employer Davita in 2 days lol). We are encouraged to push re-use primarily due to "cost containment". It cost more to use dry packs then the re-use and the company doesnt get paid any additional dollars to use dry packs. Re-use techs do the cleaning but when it comes to checking water, mixing dialysate, cultures etc it's a licensed person such as LPN, RN, or the Biomedical team that does this (at least in my state). I dont like the idea of reuse myself as a professional but then again I have patients who react to dry packs and have no choice but to use reuse also. I was informed yesterday of a new patient utilizing reuse who failed to inform our clinic they are HIV positive and has been getting reuse. We are now changing him to a dry pack although he's been with us 4 weeks now. Also the machine the patient has been assigned to hasnt been bleached between patient use as it's supposed to be because of the patients failure to inform. We found it when we got his medical records from previous health provider. Also they are supposed to check for renalin clearing every time prior to putting on a patient and also have the patient identify it is thier dialyzer being used to ensure someone elses isnt put in its place. ( I have seen this happen and patient ran entire treatment on someone elses reuse dialyzer). They may not tell you but you can and have every right to refuse reuse!!
Title: Re: Reusable dialyzers
Post by: Joe Paul on January 09, 2008, 12:05:21 AM
I have a question, how is the dialyzer cleaning done? Are the chemicals recycled, or dumped after each cleaning? I am curious because of the HIV patient mentioned above being on re-use.
Title: Re: Reusable dialyzers
Post by: plugger on January 10, 2008, 05:45:34 AM
This discussion did get me wondering what kind of reactions there are to the cleaning agents so I googled "renalin reaction" and did find this:

"The second and potentially more dangerous type of reaction is one of anaphylaxis. This is an allergic reaction mediated by an antigen antibody complex. Clinically these tend to occur within five minutes of the initation of dialysis and the symptoms may include a burning sensation at the access site, shortness of breath, chest tightness, wheezing, localized edema, flushing, itching, nausea, vomiting, abdominal cramps and hypotension. Like anaphyactic reaction it can lead to respiratory insufficiency, shock and death. These reactions may be due to the artifical membrane itself, ethylene oxide (commonly used for dialyzer sterilization), agents used for reuse (these are substances used to clean and sterilize the artifical kidney in order to allow it to be used more than one time, and include bleach, formaldehyde and renalin) and medications used in the dialysis procedure (particulary heparin, an anticoagulant almost universally used for anticoagulation of the blood prior to starting dialysis)."

http://www.medquestltd.com/articles/article9.html
Title: Re: Reusable dialyzers
Post by: Krisna on January 19, 2008, 11:26:58 PM
My center did away with the reuse program not long ago.  They switched to one kind of dialyzer and we get a new one each time.  They did away with reuse some time before moving to the new center.  When they had it though they would reuse them until the sterilization machine failed it.  It's been a while since I had to look at my dialyzer to verify it was mine but I think the average was abt 25 uses and the limit was 30.  But then I never really paid much attention to that.  We had to check the name and verify that it had passed and then initial it was ours.  Now we don't have to do that because it's new every time. 

We have computerized machines and computers that are linked to them.  All info is transferred automatically from one to the other.  The coolest part is the blood pressures are transferred automatically.  My doctor is also linked to the computer system so he knows if I have trouble with treatments.  I think they use something other than formaldehyde to sterilize the machines.