I Hate Dialysis Message Board
Dialysis Discussion => Dialysis: Pre-Dialysis => Topic started by: DrMoskowitz on January 20, 2011, 08:09:17 AM
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I'm a nephrologist. In 2002, I published an article in a peer-reviewed journal showing how to prevent 90% of dilaysis--that due to type 2 diabetes or high blood pressure (1).
Unfortunately, the media wouldn't publicize the article without an endorsement from another nephrologist. I've been waiting...
But nobody in the kidney community wants to slit their financial throat (see http://tinyurl.com/healthcrime).
Could you help me get the word out?
1. http://www.genomed.com/pdf/diabetes.technology.therapeutics.pdf
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Says the file is damaged and cant be repaired.??
What kind of studies have you done?
Why will no Nephs help you? Look for retired nephs who dont care about what may happen to there careers.
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I sent him a PM asking him to fix the file.
:waving;
Rerun, Moderator
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Didn't we hear all this before?
More spam.
8)
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I'm a nephrologist. In 2002, I published an article in a peer-reviewed journal showing how to prevent 90% of dilaysis--that due to type 2 diabetes or high blood pressure (1).
Unfortunately, the media wouldn't publicize the article without an endorsement from another nephrologist. I've been waiting...
But nobody in the kidney community wants to slit their financial throat (see http://tinyurl.com/healthcrime).
Could you help me get the word out?
1. http://www.genomed.com/pdf/diabetes.technology.therapeutics.pdf
Welcome to the forum, Dr. Moskowitz.
The title of your paper which you cited here is 'From Pharmacogenomics to Improved Patient Outcomes: Angiotensin I-Converting Enzyme as an Example' involving study of 800 COPD emphysema [chronic obstructive pulmonary disease (COPD)] patients using ACE inhibitors. Are you suggesting here that 90% of ESRD caused by diabetes and hypertension could be similarily treated with ACE inhibitors? If so, could you comment on more recent papers that suggest ACE inhibitors are ineffective, such as:
'ACE-inhibitor use does not appear to reduce the risk of end-stage renal disease in patients with diabetes and may actually increase the risk' http://www.medscape.com/viewarticle/539008
Regarding the use of Ace inhibitors, the authors wrote that: "These data suggest that in the long term, these drugs may in fact cause what they are supposed to prevent? or what they prevent in the short term may increase the risk in the long term."
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Greg, Zach is right. He's been here before, check his prior posts through his profile for his intro.
The only reply that I remember from him claimed that the dose of ACE inhibitors was too low, oh and I think he said Lisinopril does not work for some reason? (Odd. That would be the most common of the ACEs I should think.) I have read that high-dose ACE inhibitors can be really dangerous. My donor supposedly has pre-diabetes, so I was interested in researching this a little more and I seem to have found data similar to what Greg's dug up.
Dr. Moskowitz, I would be interested to hear your answers to Paul's questions, in your own words, not via links. If you seriously want help from people here, then you need to engage with us properly: answer questions, summarize your findings. I personally will not click links from people with whom I am not familiar.
Is your study FDA approved? Who is sponsoring?
I found this study on clinicaltrials.gov, where every study must be FDA approved. http://www.clinicaltrials.gov/ct2/show/NCT00283686?term=ace+inhibitor+polycystic&rank=1 (http://www.clinicaltrials.gov/ct2/show/NCT00283686?term=ace+inhibitor+polycystic&rank=1)
It is called HALT PKD and is investigating the effects of Lisinopril and Telmisartan (ACE and ARB) vs. ACE monotherapy.
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:rofl; I did a web search and found him. He's also suggesting ACE inhibitors to treat West Nile virus in horses.
"West Nile Trial For Horses: GenoMed's patent-pending approach, which uses a class of blood pressure pills to gently reduce excessive inflammation by a patient's own immune system, has achieved a 100% response rate so far among 12 patients with an intact immune system who came down with West Nile virus encephalitis. If GenoMed's approach continues to work in humans (which remains to be seen; 12 is still a small number), it should also work in horses and birds. Dr. Moskowitz stated; “Essentially there are no side effects. The dose used won’t lower a horse’s blood pressure at all, I should think. The only other side effect of an ARB, namely angioedema, is extremely rare, at least in humans. It occurs in about 1% of humans who use an ACE inhibitor, so in 100 out of 10,000 people who use an ACE inhibitor. Of these, it occurs in only 3 people who then get switched to an ARB. So 3 out of 10,000 is a pretty rare side effect. If your horse is in need of treatment for West Nile Virus your Veterinarian may contact Dr. Moskowitz at ..." (link removed)
Editing to add this, quoted from another message board in 2004:
"I did some snooping. Dr. Moskowitz IS selling something. He hopes to eventually market the use of ACE inhibitors for a profit. Nothing inherently wrong with that, but I have a few concerns. His site says:
'GenoMed invites physicians to join its Clinical Outcomes Improvement NetworkTM in order to bring the latest in genomics-based medicine to your patients. Of the $800 annual subscription fee paid by your patient to belong to GenoMed's COIPTM, the physician is paid $200 in exchange for managing the patient and updating GenoMed on the patient's clinical course. Thus, a physician with 1,000 hypertensive or diabetic patients in his/her panel could earn an extra $200,000 annually while delivering superior outpatient preventive care.'
Apparently, the "Clinical Outcomes Improvement Program" (a term that is actually trademarked) is not a formal clinical trial. Will the patients who purchase this membership first be informed that their own physicians are receiving a financial incentive for promoting the therapy? There is a conflict in such a patient/physician relationship that I doubt will be made transparent. Will the "clinical outcomes" be reported in an unbiased way?
Might he eventually promote this therapy for "post-lyme" symptoms to the exclusion of antibiotics? The last thing we need is a company with a financial interest in rejecting evidence of chronic lyme infection.
It turns out that ACE inhibitors and ARBs are separate classes of drugs that nonetheless achieve similar anti-inflammatory effects. I checked Dr. Moskowitz's patent applications and it appears that he claims a right to the use of ARBs only when combined with the ACE inhibitors. But the people at www.sarcinfo.com use the ARBs quite successfully without combining them with the ACE inhibitors. So why would anyone pay Dr. Moskowitz's licensees' for the privilege of using ACE or ACE+ARB when ARBs alone will work?
The mere discussion here of the possible use of ARBs for Lyme should constitute "public disclosure" and should therefore preclude any right to patent the use of ARBs for Lyme. I'm therefore uncomfortable with the prospect of a company with the incentive to marginalize the evidence that ARBs may be an effective surrogate for ACE inhibitors.
If you want info on this from people who in fact have no financial incentives, see www.sarcinfo.com They explain the rationale behind this approach in much greater depth than you will find at Dr. Moskowitz's web site."
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I'm a nephrologist. In 2002, I published an article in a peer-reviewed journal showing how to prevent 90% of dilaysis--that due to type 2 diabetes or high blood pressure (1).
Unfortunately, the media wouldn't publicize the article without an endorsement from another nephrologist. I've been waiting...
But nobody in the kidney community wants to slit their financial throat (see http://tinyurl.com/healthcrime).
Could you help me get the word out?
1. http://www.genomed.com/pdf/diabetes.technology.therapeutics.pdf
Dr. Moskowitz, it is interesting what you write.
My problem is that once during a Lupus/SLE/MCTD flare-up
I was prescribed all sorts of anti-inflammatories and ACE-inhibitors
and I had an allergic reaction to all. (I suffer from drug-intolerance).
I am also hypertensive and only can tolerate
one particular type of anti-hypertensives.
I am still pre-dialysis with a kidney function of 10-12%
Is there anything else practical you could suggest
for me to keep my kidneys functioning longer
and/or to get them better again?
Thanks, Kristina.
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Dont feed the troll , one finds its way to the forum every now and again with a fantastic solution or cure. ::)