I Hate Dialysis Message Board
Welcome,
Guest
. Please
login
or
register
.
October 31, 2024, 06:26:56 AM
1 Hour
1 Day
1 Week
1 Month
Forever
Login with username, password and session length
Search:
Advanced search
532606
Posts in
33561
Topics by
12678
Members
Latest Member:
astrobridge
I Hate Dialysis Message Board
Dialysis Discussion
Dialysis: General Discussion
How many allels matched????
0 Members and 1 Guest are viewing this topic.
« previous
next »
Pages:
[
1
]
Author
Topic: How many allels matched???? (Read 2817 times)
donnia
Elite Member
Offline
Gender:
Posts: 1012
me and my donor Joyce
How many allels matched????
«
on:
January 09, 2008, 07:26:53 AM »
If you have had a transplant before, how many allels (sp?) matched? How well did that kidney work after you got it???
Is 2 out of 6 an okay match?
Logged
Born with one kidney 1972
Ureter re-constructured 1975 (reflux had already damaged the kidney)
Diagnosed and treated for high blood pressure 2000
Diagnosed ESRF October 2006
Started dialysis September 2007
Last dialysis June 4, 2008
Transplant from my hero, Joyce, June 5, 2008
petey
Newbie
Offline
Gender:
Posts: 0
MEMBER BANNED
Re: How many allels matched????
«
Reply #1 on:
January 09, 2008, 10:51:14 AM »
When I gave my husband a kidney (2000), we were a 1 out of 6 antigen match. Before the surgery, his doctors prepared us that it could possibly reject. Didn't happen! His body accepted it, and the kidney started working in him while he was still on the operating table. He did lose the kidney three years later -- but not because of a rejection. The disease that destroyed his original kidneys (IGA nephropathy) attacked the transplanted kidney and destroyed it, too. They've come so far with antirejection meds that a lower match is easier to keep than it was years ago.
Logged
okarol
Administrator
Member for Life
Offline
Gender:
Posts: 100933
Photo is Jenna - after Disneyland - 1988
Re: How many allels matched????
«
Reply #2 on:
January 09, 2008, 11:00:58 AM »
Jenna's donor was 1 of 6 match. The neph told us that the antibody crossmatch is much more of a concern, and that a 0 of 6 match from a living donor is a lot better than a 6 of 6 match from a deceased donor.
Logged
Admin for IHateDialysis 2008 - 2014, retired.
Jenna is our daughter, bad bladder damaged her kidneys.
Was on in-center hemodialysis 2003-2007.
7 yr transplant lost due to rejection.
She did PD Sept. 2013 - July 2017
Found a swap living donor using social media, friends, family.
New kidney in a paired donation swap July 26, 2017.
Her story --->
https://www.facebook.com/WantedKidneyDonor
Please watch her video:
http://youtu.be/D9ZuVJ_s80Y
Living Donors Rock!
http://www.livingdonorsonline.org
-
News video:
http://www.youtube.com/watch?v=J-7KvgQDWpU
donnia
Elite Member
Offline
Gender:
Posts: 1012
me and my donor Joyce
Re: How many allels matched????
«
Reply #3 on:
January 09, 2008, 01:41:11 PM »
Great! One of my donors just told me that she is a match for me....2 out of 6. So I was just wondering.
Logged
Born with one kidney 1972
Ureter re-constructured 1975 (reflux had already damaged the kidney)
Diagnosed and treated for high blood pressure 2000
Diagnosed ESRF October 2006
Started dialysis September 2007
Last dialysis June 4, 2008
Transplant from my hero, Joyce, June 5, 2008
stauffenberg
Elite Member
Offline
Posts: 1134
Re: How many allels matched????
«
Reply #4 on:
January 09, 2008, 07:31:03 PM »
Keep in mind that there are hundreds of HLA groups which determine the immunological signature of a person's organs, and that of these only six, or at some centers now, only eight, are being taken into account to 'match' one person to another for transplant. A transplant from a close relative is thus always better if possible, since in addition to the tested matching HLA sites, there are likely to be many more untested ones which match. The six or eight tested for matching are just those presently believed to be the most important for immunological compatibility.
Of the HLA groups, the most important for the immunological success of the transplant is the DR group, so always ask if that is one of the ones found to match.
In addition to the HLA matching, the number of pre-formed antigens to foreign renal tissue is important, and this is tested by the cross-matching.
Other factors found to have a positive influence on the survival of the graft are 1) a young donor; 2) a male donor; 3) a living donor; and 4) low warm ischemia time elapsed before transplantation.
The main cause of graft loss now is no longer rejection but chronic allograft nephropathy -- a multi-factorial process poorly understood and unable to be prevented by any known medical intervention. It may have subclinical immunological components, but it seems also to have some connection with higher blood pressure and higher blood lipid levels in the graft recipient.
Logged
plugger
Sr. Member
Offline
Gender:
Posts: 654
I only look like a sheep - but I ain't
Re: How many allels matched????
«
Reply #5 on:
January 10, 2008, 05:22:31 AM »
My daughter matched 3 out of 6 and has had the kidney for over seven years now. I did want to mention she went through a period where her labs were slowly getting worse. She was switched from neoral to prograf and finally to myfortic before she started getting better. As far as I can tell getting the right drugs after the transplant is an art with people responding differently to different drugs.
Logged
Proud member of DialysisEthics since 2000
DE responsible for:
*2000 US Senate hearings
*Verified statistics on "Dialysis Facility Compare"
*Doctors have to review charts before they can be reimbursed
*2000 and 2003 Office of Inspector General (OIG) reports on the conditions in dialysis
*2007 - Members of DialysisEthics worked for certification of hemodialysis
technicians in Colorado - bill passed, renewed in 2012 and 2019
*1999 to present - nonviolent dismissed patients returned to their
clinics or placed in other clinics or hospitals over the years
On my tombstone: He was a good kind of crazy
www.dialysisethics2.org
donnia
Elite Member
Offline
Gender:
Posts: 1012
me and my donor Joyce
Re: How many allels matched????
«
Reply #6 on:
January 16, 2008, 02:13:08 PM »
I found out that we matched A2 and A31..... no DR..... but at least she is a match
Logged
Born with one kidney 1972
Ureter re-constructured 1975 (reflux had already damaged the kidney)
Diagnosed and treated for high blood pressure 2000
Diagnosed ESRF October 2006
Started dialysis September 2007
Last dialysis June 4, 2008
Transplant from my hero, Joyce, June 5, 2008
Pages:
[
1
]
« previous
next »
Loading...