I Hate Dialysis Message Board
Welcome, Guest. Please login or register.
March 28, 2024, 09:50:49 AM

Login with username, password and session length
Search:     Advanced search
532606 Posts in 33561 Topics by 12678 Members
Latest Member: astrobridge
* Home Help Search Login Register
+  I Hate Dialysis Message Board
|-+  Dialysis Discussion
| |-+  Dialysis: Medical Breakthroughs
| | |-+  Newly discovered protein may protect kidney cells from injury
0 Members and 1 Guest are viewing this topic. « previous next »
Pages: [1] Go Down Print
Author Topic: Newly discovered protein may protect kidney cells from injury  (Read 2708 times)
Zach
Elite Member
*****
Offline Offline

Gender: Male
Posts: 4820


"Still crazy after all these years."

« on: September 03, 2015, 05:37:35 AM »

Newly discovered protein may protect kidney cells from injury

http://www.eurekalert.org/pub_releases/2015-09/bumc-ndp090215.php

PUBLIC RELEASE: 2-SEP-2015
BOSTON UNIVERSITY MEDICAL CENTER

(Boston)--A new discovery by Boston University School of Medicine (BUSM) researchers may change how kidney disease is treated in the future.

The previously unknown protein transmembrane and immunoglobulin containing 1 (TMIGD1) involved in protecting kidney epithelial cells (cells critical to normal kidney function) from injury, could be a novel target for restoring kidney function from various forms of kidney disease. The findings are published online in the American Journal of Pathology.
http://ajp.amjpathol.org/article/S0002-9440(15)00376-4/abstract

Kidneys have several roles, of which filtering blood of waste products to generate urine is the primary function. Kidneys can fail over days, known as acute kidney injury (AKI), or can develop over years, known as chronic kidney disease (CKD), an irreversible form of kidney failure. Both forms of kidney failure are common and represent a tremendous health care burden. Kidney failure among inpatients not only lengthens hospital stays but also indicates overall poor prognosis. Nearly 20 million people, or 10 percent, of the U.S. population suffers from CKD primarily from diabetes and hypertension, consuming approximately $32.8 billion of Medicare budget.

Researchers reduced expression of TMIGD1 in kidney epithelial cells and demonstrated that they become susceptible to cell injury, whereas increasing TMIGD1 expression protected these cells from injury. "This study demonstrates that by altering the function of TMIGD1, it is possible to reduce kidney epithelial cell death and possibly avoid the high incidence of kidney failure and morbidity associated with kidney injury," explained corresponding author Nader Rahimi, PhD, associate professor of pathology and laboratory medicine at BUSM.

TMIGD1 belongs to a new class of proteins involved in cell-cell recognition. The first member of TMIGD1 called IGPR-1, was identified by the same group of researchers in early 2012. IGPR-1 is involved in tumor angiogenesis, or the development of new blood vessels.

"While dialysis and transplantation are considered the cornerstone of therapy for both forms of renal failure, none of these strategies directly targets the kidney proximal epithelial cells. Therapeutic agents that could protect these cells from death can prevent and retard renal damage, thus postponing dialysis or need for transplantation," added study co-author Vipul Chitalia, MD, PhD, assistant professor of medicine at BUSM and a nephrologist at Boston Medical Center.

###

Funding for this study was provided in part by the National Institutes of Health through grant award numbers R21 CA191970 and R01 CA175382. Emad Arafa, a graduate student and Philip Bondzie, a postdoctoral fellow at Boston University, are the co-primary authors.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
« Last Edit: September 03, 2015, 05:44:19 AM by Zach » Logged

Uninterrupted in-center (self-care) hemodialysis since 1982 -- 34 YEARS on March 3, 2016 !!
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
No transplant.  Not yet, anyway.  Only decided to be listed on 11/9/06. Inactive at the moment.  ;)
I make films.

Just the facts: 70.0 kgs. (about 154 lbs.)
Treatment: Tue-Thur-Sat   5.5 hours, 2x/wk, 6 hours, 1x/wk
Dialysate flow (Qd)=600;  Blood pump speed(Qb)=315
Fresenius Optiflux-180 filter--without reuse
Fresenius 2008T dialysis machine
My KDOQI Nutrition (+/ -):  2,450 Calories, 84 grams Protein/day.

"Living a life, not an apology."
Pages: [1] Go Up Print 
« previous next »
 

Powered by MySQL Powered by PHP SMF 2.0.17 | SMF © 2019, Simple Machines | Terms and Policies Valid XHTML 1.0! Valid CSS!