Hello all. I have posted on this forum before but it has been quite awhile. We have been doing NxStage at home for a little over 2 weeks now. Things have been so crazy hectic between work and rushing home to get him on the machine, etc. I have noticed that after the last few treatments, we have had some clotting issues. Mostly in the port on the dialyzer but after the last couple, there have been a few clots in the access pod and the lines are not running all the way clear. We are using a CVC currently until the fistula is usable. I ALWAYS check for clots pre treatment and usually never have any. But last night, after checking for clots, when I went to administer the 2000 u of heparin (pre-treatment), I pulled back on the syringe to pull out a couple of tiny air bubbles. When I did that, a pretty sizeable clot appeared. I removed it, but where did it even come from? After tonight's treatment and the most clotting we have had so far, I called the nurse. We are going to up the heparin to 3000 u tomorrow night. But I am still confused, because we have had no alarms. If there was a clotting issue, wouldn't it trigger an alarm? Also, after a few treatments, especially since the clotting issue has popped up, the saline in the bag has been red? The nurse had no idea about that one, except maybe I forgot to unclamp the venous line after re - attaching it to the saline spike. I doubled checked after she asked me that. I had not yet broken everything down. All the clamps that were supposed to be clamped - were. I am very frustrated. As far as I am aware, I am doing everything exactly the way it is supposed to be done, yet these little issues keep coming up in the last few days. And I would like to find a solution before it becomes a massive issue that causes a new alarm and another mini heart attack on my part....Thanks in advance for your replies. You may be saving my sanity