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Author Topic: prednisolone and cyclosporin at same time?  (Read 8038 times)
lou
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« on: October 23, 2010, 03:20:57 AM »

Hi everyone, i have a question which may sound a bit silly but would love your opinions!

I am now 7 months since my transplant and fingers crossed all is going well!!! I am taking 7.5 prednisolone every morning about 9am with breakfast and then cyclorporin (125) at 11am and (100) at 11pm. My question is do you think i could take my presnisolone at 11am with the first dose of cyclorsporin? Then i would just take the pills at 11am and 11pm.

I know it may seem a stupid question but i just think it would so much easier to just have two time a day to remember and as my break at work is 11am i would be able to just take them all then. I did ask my doc at transplant clinic on Monday and he said he thinks (thinks?!!) it would be ok and there is no reason why they cant be taken at the same time but i am too scared to change it.
Incase you haven't noticed i am a MASSIVE worrier when it comes to the kidneys!! Just sooooo amazing grateful for this kidney and i guess as things are going so well too scared to change anthing in case i jinx something! On the otherhand would love to just take pills at 11 and 11 and sure it would be fine.

Does anyone else take these pills at the same time each day?  ???
Am i just turning into a compete mental case?  :banghead;
Any ideas would be great?

Thanks for reading, love x x
« Last Edit: October 23, 2010, 03:22:35 AM by lou » Logged
Rerun
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« Reply #1 on: October 23, 2010, 05:28:27 AM »

You should ask your pharmacist, but I don't see a problem with it.  Your body knows what to do with the meds.  It is amazing the handfull of pills I take and it all goes where it is supposed to. 
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lou
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« Reply #2 on: October 23, 2010, 06:03:25 AM »

Thanks rerun, i actually hadn't thought of asking the pharmacist but that makes a lot of sense. The body is pretty amazing isnt it!
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Riki
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« Reply #3 on: October 23, 2010, 10:35:27 AM »

I seem to remember that you're not supposed to take it at the same time, but I don't remember why.. it would probably be best to ask the pharmacist.. they'd know better.. it's been years since I've taken either drug, so..
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transplant - Oct 1, 1992- Apr 2001
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rsudock
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« Reply #4 on: November 05, 2010, 06:43:49 PM »

Hello,
 I have been taking prednisone and Neoral (cyclosporine) at the same time for years. Just make sure to take it with food as prednisone can really upset your stomach....use to work in a pharmacy too!

xo,
R
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Born with autosomal recessive polycystic kidney disease
1995 - AV Fistula placed
Dec 7, 1999 cadaver transplant saved me from childhood dialysis!
10 transplant years = spleenectomy, gall bladder removed, liver biopsy, bone marrow aspiration.
July 27, 2010 Started dialysis for the first time ever.
June 21, 2011 2nd kidney nonrelated living donor
September 2013 Liver Cancer tumor.
October 2013 Ablation of liver tumor.
Now scans every 3 months to watch for new tumors.
Now Status 7 on the wait list for a liver.
How about another decade of solid health?
monrein
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« Reply #5 on: November 05, 2010, 06:50:19 PM »

I always took mine at the same time (20 years until I was switched to Cellcept).  Now with this new trx I take it at the same time as cellcept and Prograf.
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Pyelonephritis (began at 8 mos old)
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Haemo-dialysis, self care unit June 2008
(2 1/2 hours X 5 weekly)
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natnnnat
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« Reply #6 on: November 06, 2010, 05:19:28 AM »

Before he got this pneumonia Gregory took his prednisolone and his cellcept together, like this:
in the morning 2x 5ml predisolone and a cellcept (cyclosporin), a sodibic and half a betaloc
then at night half a betaloc, and another cellcept.

Different at present but hopefully he'll get back to this low dose.   Hope this helps.   
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Natalya – Sydney, Australia
wife of Gregory, who is the kidney patient: 
1986: kidney failure at 19 years old, cause unknown
PD for a year, in-centre haemo for 4 years
Transplant 1 lasted 21 years (Lucy: 1991 - 2012), failed due to Transplant glomerulopathy
5 weeks Haemo 2012
Transplant 2 (Maggie) installed Feb 13, 2013, returned to work June 17, 2013 average crea was 130, now is 140.
Infections in June / July, hospital 1-4 Aug for infections.

Over the years:  skin cancer; thyroidectomy, pneumonia; CMV; BK; 14 surgeries
Generally glossy and happy.

2009 - 2013 PhD research student : How people make sense of renal failure in online discussion boards
Submitted February 2013 :: Graduated Sep 2013.   http://godbold.name/experiencingdialysis/
Heartfelt thanks to IHD, KK and ADB for your generosity and support.
Meinuk
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« Reply #7 on: November 06, 2010, 06:30:39 AM »

I was told that if you are on a single dose of prednisone (same corticosteroid family as prednisolone), it is best to take it before 9am - in order to follow your body's natural circadian rhythm.  (provided you don't work the night shift)

Also, Cellcept is NOT cyclosporine.  It is mycophenolate mofetil. http://www.drugs.com/cellcept.html

Many times Mycophenolate and cyclosporine are given together, but Tacrolimus (Prograf) http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000103 has become more widely used in recent years.

My protocol is:   Prograf (4mg), Cellcept (1000mg) and Prednisone (5mg) at 8am and CellCept (500mg) and Prograf (4mg) at 8PM.
« Last Edit: November 06, 2010, 06:36:09 AM by Meinuk » Logged

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52 with PKD
deceased donor transplant 11/2/08
nxstage 10/07 - 11/08;  30LS/S; 20LT/W/R  @450
temp. permcath:  inserted 5/07 - removed 7/19/07
in-center hemo:  m/w/f 1/12/07
list: 6/05
a/v fistula: 5/05
NxStage training diary post (10/07):  http://ihatedialysis.com/forum/index.php?topic=5229.0
Newspaper article: Me dialyzing alone:  http://ihatedialysis.com/forum/index.php?topic=7332.0
Transplant post 11/08):  http://ihatedialysis.com/forum/index.php?topic=10893.msg187492#msg187492
Fistula removal post (7/10): http://ihatedialysis.com/forum/index.php?topic=18735.msg324217#msg324217
Post Transplant Skin Cancer (2/14): http://ihatedialysis.com/forum/index.php?topic=30659.msg476547#msg476547

“To doubt everything or to believe everything are two equally convenient solutions; both dispense with the necessity of thought.” - Henri Poincare
natnnnat
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« Reply #8 on: November 06, 2010, 06:59:59 AM »

blush.  that'll teach me to type what gregory says.  Useful website btw, this drugs.com.
Doesn't say anything about prednisolone making you shake ... I wonder if the shaking is some other thing then.  Hmmm.
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Natalya – Sydney, Australia
wife of Gregory, who is the kidney patient: 
1986: kidney failure at 19 years old, cause unknown
PD for a year, in-centre haemo for 4 years
Transplant 1 lasted 21 years (Lucy: 1991 - 2012), failed due to Transplant glomerulopathy
5 weeks Haemo 2012
Transplant 2 (Maggie) installed Feb 13, 2013, returned to work June 17, 2013 average crea was 130, now is 140.
Infections in June / July, hospital 1-4 Aug for infections.

Over the years:  skin cancer; thyroidectomy, pneumonia; CMV; BK; 14 surgeries
Generally glossy and happy.

2009 - 2013 PhD research student : How people make sense of renal failure in online discussion boards
Submitted February 2013 :: Graduated Sep 2013.   http://godbold.name/experiencingdialysis/
Heartfelt thanks to IHD, KK and ADB for your generosity and support.
Meinuk
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« Reply #9 on: November 06, 2010, 07:19:38 AM »

hah! you should hear some of the words that come out of my addled mind before I have had coffee in the morning....

My favorite this week while walking out the door at 7:45 am for work, I said "Good Night".

 :)

FYI, prograf makes me shake like I have the dt's (which usually leaves me with A LOT of explaining to do when people don't know about my medical issues...)
« Last Edit: November 06, 2010, 07:21:11 AM by Meinuk » Logged

Research Dialysis Units:  http://projects.propublica.org/dialysis/

52 with PKD
deceased donor transplant 11/2/08
nxstage 10/07 - 11/08;  30LS/S; 20LT/W/R  @450
temp. permcath:  inserted 5/07 - removed 7/19/07
in-center hemo:  m/w/f 1/12/07
list: 6/05
a/v fistula: 5/05
NxStage training diary post (10/07):  http://ihatedialysis.com/forum/index.php?topic=5229.0
Newspaper article: Me dialyzing alone:  http://ihatedialysis.com/forum/index.php?topic=7332.0
Transplant post 11/08):  http://ihatedialysis.com/forum/index.php?topic=10893.msg187492#msg187492
Fistula removal post (7/10): http://ihatedialysis.com/forum/index.php?topic=18735.msg324217#msg324217
Post Transplant Skin Cancer (2/14): http://ihatedialysis.com/forum/index.php?topic=30659.msg476547#msg476547

“To doubt everything or to believe everything are two equally convenient solutions; both dispense with the necessity of thought.” - Henri Poincare
Riki
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« Reply #10 on: November 06, 2010, 03:04:13 PM »

Cyclosporine used to make me shake almost uncontrollably in the beginning.  I remember being yelled at by teachers because I wasn't keeping up with notes, and they just didn't understand that I couldn't write as fast as I could before because of the shaking.  That was before they changed the formula.  I remember a lot of kids losing their kidneys when they changed over.  I was lucky that it didn't affect me.
« Last Edit: November 06, 2010, 03:05:26 PM by Riki » Logged

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paris
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« Reply #11 on: November 06, 2010, 05:24:34 PM »

Prograf is the source of my tremors.  It was just reduced this week to 2 pills - 2 times a day.  I was told the tremors will get lower as the Prograf level is lowered.

Did you find an answer to taking the pills together?  I am not on prednisone, but do take Procraf and Cellcept together.   Let us know what you find out.
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lou
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« Reply #12 on: November 09, 2010, 12:28:13 PM »

wow, haven't been on for a few days so thanks for all the replies. well i checked at the pharmacy and they seemed to also think it was ok to take them together. as im a worrier ( :banghead;) am going to start taking them together a few days before my next blood test and then all being well will stick to that!

love ihd, i never feel like too much of an idiot asking these questions here as just feel like you all really understand why even little things like this are a worry. love you all! x xx
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lola
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« Reply #13 on: November 09, 2010, 04:33:28 PM »

Otto took his at the same time for 16 years...........
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paris
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« Reply #14 on: November 10, 2010, 04:37:39 PM »

Fortunately, we all ask what we think are stupid questions, but it is wonderful to get answers so quickly here instead of waiting to call the clinic!   We all care about you and want things to go well for you     :cuddle;   Let us know how the next lab results look.   :2thumbsup;
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It's not what you gather, but what you scatter that tells what kind of life you have lived.
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