My husband and I are still new to this whole Nxstage thing. We had a problem today they I could not seem to fix and I am hoping someone here can help me if it happens again. We just stated using new cartridges lot #0047707 and so far we have had a problem every treatment. The first one we used we got alarm code 86 after following all the instruction in the book we got it again and had to replace the cartridge. Every other one so far we have had high arterial pressure, not to high but high enough to alarm and make us lower our blood flow which we normally do at 450, we have had to stay at 440. Today we were able to get to 450 no problem and his arterial pressure was under 200, then about 45 minutes into treatment it went up to about 230. I repositioned the needle a few times even flipped it but we still were getting high pressure. Then I reset the pressure pod (my first time doing this) his pressure was still high, but I realized I did it wrong and attached to monitoring line before I hit treatment, so I did it again, this time correctly. then his pressure was only like 30 and the access pressure pod was full of saline and not blood, I am not sure what I did wrong, but I knew something was not right so I reset it again. Pressure pod was full of blood but his pressure was still high so I just did a manual rinse back. I'm hoping someone here can tell me if there was anything else I could have done, or if you have any suggestions? Any input would be appreciated.