NxStage skip days are more flexible. For billing purposes we are told to always take ours on the same day, but the general rule is you get one day a week to skip when you choose. Just don't ever skip two in a row.In-center is rough on the body in general. I remember some holidays/family emergencies where Jenn had to miss a Monday or Friday treatment. Skipping one of the 3/week treatments is very hard on your body and usually takes a few treatments to recover from.Don't ever be seen as non-compliant. Those folks that give out transplants keep files on all of us. We saw ours once, it was disturbing. You'll think judgment day, death panels, big brother, etc. is real if you ever see yours. They will write down subjective "observations" that don't have to be proven or agreed upon as fact by you. The less they know the better. Don't give them any negative ammunition.