Yeah, that must be referring to antibodies. It means you are moderately sensitized (don't panic). They've taken the unusual step of dividing it into the 2 classes. Sensitization in Class 2 is slightly more serious, so at least that is the lower number. I am going to guess that you are sensitized to 63 percent of class 1 antigens and 47 percent of class 2, putting your overall PRA at 55%.If that is the case, this means that your system will likely reject 55% of available donors immediately. Not great news, but it obviously could be much worse. Do you remember anything the coordinator said, and could you share it? Perhaps some word will spark recognition.
Whilst they may be finding more antigens because of increased sensitivity of tests, this also has the converse effect that transplants thatwere deemed unsuitable in the past, may now be considered suitable. What I mean is that before a test would identify a,b and c antibodies as one type whereas now the tests are sensitivie enough to determine them as three different antibody types. So in the past, someone could be sensitised to antigen a, but not antigen b so the transpant would not go-ahead, whereas now, by being able to differentiate between a,b and c antigens, would mean that this person would only not be able to receive from a donor with a antigens but one with b or c antigens would be a go. Sorry if I haven't explained this very well, but this is my understanding from the explanation given to me by my transplant surgeon when I joined the Highly sensitised patient program at John Hopkins. Of course, it may have been that he was trying to make me feel better in a near hopeless situation, since it was my husband that was informed that I was one of thhe most highly sensitised patients that they have ever come across ,but I was not told this. My problem is, that not only is my PRA at 99% but Also that I am sensitised against so many antigens.