No, it isn't just you. Life can be overwhelming at the best of times and ESRD magnifies that by about a thousand even when all is going as well as can be expected. Throw in a little or a big medical complication, some financial stress, emotional turbulence, add some normal aging and it can quickly equal the major blues if not outright clinical depression.
There's no trick that works for everyone but we each plod along and try to find ways to cope that feel acceptable. Talking can help, feeling understood can help, exercise can help, taking control of whatever you can control is good, finding pleasure in the small things never hurt and focusing on positive things that feed your passion is a good distraction.
All so easy to type but hard to do. Above all, I think it's important to laugh as much as possible and find the funny in the tragic. Life is too serious to be taken too seriously all the time.