Depression may increase the risk of kidney failure

Depression may increase the risk of kidney failure
3/10/2011

Depression is associated with an increased risk of developing kidney failure in the future, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology.

Lead investigator, Dr. Willem Kop (Department of Medical Psychology and
Neuropsychology at the University of Tilburg, the Netherlands) and colleagues studied 5,785 people from four counties across the United States for 10 years. The participants were 65 years and older and not yet on dialysis. They completed a questionnaire measuring depressive symptoms and a broad range of medical measurements, including estimated glomerular filtration rate and risk factors for kidney and heart diseases. The investigators examined whether depression predicted the onset of kidney disease or other medical problems in which the kidneys play a critical role.

According to the results, depression coincided with the presence of chronic kidney disease (CKD) and was 20% more common in individuals with kidney disease than those without kidney disease. The study shows that depression predicted subsequent rapid decline in kidney function, new onset clinically severe kidney disease, and hospitalizations that were complicated by acute kidney injury. When the investigators corrected for the long-term effects of other medical measures, the predictive value of depression for hospitalizations with acute kidney injury remained high.

The investigators are currently analyzing which factors may explain the association with depression, which could include delayed seeking of medical care and miscommunications between patient and physicians and important biological processes associated with depression, such as the immune and nervous systems.

Disclosures: The project is based on the Cardiovascular Health Study, in collaboration with the Department of Medicine of the University of Maryland at Baltimore and other institutions throughout the United States and funded by the National Heart Lung and
Blood Institute of the National Institutes of Health. The article, entitled “Longitudinal Association of Depressive Symptoms with Rapid Kidney Function Decline and Adverse Clinical Renal Disease Outcomes,” appears online at http://cjasn.asnjournals.org.

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