Chronic Kidney Disease Should Not Prevent Women From Taking The Osteoporosis Med

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Chronic Kidney Disease Should Not Prevent Women From Taking The Osteoporosis Drug Raloxifene, Study Suggests

ScienceDaily (Apr. 9, 2008) — The osteoporosis drug raloxifene increases bone mineral density and reduces the risk of vertebral fractures among postmenopausal women with mild to moderate chronic kidney disease (CKD), according to a new study. The findings indicate that raloxifene is safe and effective for women with CKD, a patient population often excluded from studies of osteoporosis drugs.

Because CKD may lead to metabolic abnormalities that accelerate bone loss, it is important to monitor bone mineral density levels in these patients and to administer treatments when levels are low. However, the use of osteoporosis therapies for patients with this disease is highly controversial, given the drugs' previously unknown effectiveness and safety in these individuals.

To determine whether raloxifene is a suitable treatment option for women with CKD, Dr. Areef Ishani, of the Minneapolis VA Medical Center and University of Minnesota, in Minneapolis, MN, and his colleagues analyzed data from the Multiple Outcomes of Raloxifene Evaluation (MORE), a multi-center, randomized, placebo-controlled trial of 7,705 postmenopausal women with osteoporosis. They examined the effect of raloxifene over three years on the rate of change of bone mineral density, incidence of fractures, and adverse effects in women with and without CKD.

The investigators found that irrespective of kidney function, patients taking raloxifene experienced a greater increase in spine bone mineral density and a reduction in vertebral fractures compared with patients taking a placebo. Raloxifene also increased hip bone mineral density, most prominently in women with mild to moderate CKD.

The study's results have significant clinical relevance because many postmenopausal women have unidentified CKD. The findings are reassuring in that raloxifene can safely be used in women who have decreased kidney function.

The study, entitled, "The Effect of Raloxifene Treatment in Postmenopausal Women with CKD," will be available online beginning April 9, 2008 at the website of the Journal of the American Society Nephrology. It will be published in the July 2008 issue.

American Society of Nephrology (2008, April 9). Chronic Kidney Disease Should Not Prevent Women From Taking The Osteoporosis Drug Raloxifene, Study Suggests. ScienceDaily. Retrieved April 11, 2008, from http://www.sciencedaily.com­ /releases/2008/04/080409120622.htm

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The problem is that these drugs used to counter osteoporosis increase the burden of electrolytes in the body for the kidneys to excrete.  Also, to work effectively, they require the patient to take high doses of calcium, which in patients with reduced renal function can cause calcium deposits in the veins which contribute to arteriosclerosis.