Just spoke to NxStage about making changes to rates during treatment and Red Alarm 10. Changing the UF and Dialysate rates during treatment should not set off RA10 but a change to the Blood Flow Rate might, as it could cause micro-bubbles to form in the Access Pressure Pod. The Red Alarm 10 involves possible problems that begin on the Arterial Access side, perhaps the arterial needle moved or became dislodged or the line got kinked due to the patient moving their arm, etc...in other words, some sort of change in movement to the arterial blood flow, which of course, ends up affecting the Venous side of things. The night I had a RA10, I remember making changes to the UF and Dialysate rates and altho not immediately, several minutes later the RA10 occurred. Altho I don't remember, it is possible that I had also changed my husband's Blood Flow Rate and then changed it back to what it was thus, upsetting the proverbial apple cart and affecting the Access Pressure Pod. I have had to change his Blood Flow Rate during treatment before but perhaps this last time, I went back and forth with it and too rapidly, creating little micro-bubbles to build up in the Access Pod and setting off the RA10.