No. The higher the more your blood get clean and the more time you spend (maybe 15 more minutes). It's a good thing.
? The higher the FF the faster the dialysate goes, the shorter the run. If you increase the amount of dialysate you're using 25% I would say you're coming out ahead but if you raise FF and keep the amount of dialysate the same you are getting >less< clearance.
EDITED TO ADD: In rough terms the FF is the rate of dialysate flow as a percentage of the rate of blood flow. If your blood flow is 500 then at a FF of 35 your dialysate is going through the machine at a rate of 175cc/min or 10.5 liters/hour. At an FF of 40 the dialysate is going through the machine at 200cc/min or 12 liters/hour.
20 Liters at 10.5 an hour is about 1hour 54minutes; your actual run length is longer because the amount of fluid you're removing also effects run length (and all these calculations), but if you assume you're taking off the same amount of fluid then the 25 liter run at 40FF should take longer - about a 2h 5m base vs. the previous base of 1h 54m.