Does anyon have itching skin? I thought it was the pain med, but I still itch. The DR told me to stop taking the Bactrim for a week. I have missed one dose and the itching is mostly at night. It started in the hospital, and I itched at my grand daughters house. I am taking Benadryl but it does not help. I am going crazy. It is not bad during the day, but at night it night it is unbearable at night.