Species distribution and susceptibility profile of Candida species in a Brazilian public tertiary hospitalSpecies identification and antifungal susceptibility tests were carried out on 212 Candida isolates obtained from bloodstream infections, urinary tract infections and dialysis-associated peritonitis, from cases attended at a Brazilian public tertiary hospital from January 1998 to January 2005.FindingsCandida albicans represented 33% of the isolates, Candida parapsilosis 31.1%, Candida tropicalis 17.9%,Candida glabrata 11.8%, and others species 6.2%. In blood culture, C.
parapsilosis was the most frequently encountered species (48%). The resistance levels to the antifungal azoles were relatively low for the several species, except for C.
tropicalis and C. glabrata.
Amphotericin B resistance was observed in 1 isolate of C. parapsilosis.
Conclusions: The species distribution and antifungal susceptibility herein observed presented several epidemiological features common to other tertiary hospitals in Latin American countries.
It also exhibited some peculiarity, such as a very high frequency of C. parapsilosis both in bloodstream infections and dialysis-associated peritonitis.
C. albicans also occurred in an important number of case infections, in all evaluated clinical sources.
C. glabrata presented a high proportion of resistant isolates.
The data emphasize the necessity to carry out the correct species identification accompanied by the susceptibility tests in all tertiary hospitals.
Author: Ariane Bruder-NascimentoCarlos Henrique CamargoMaria Fatima SugizakiTerue SadatsuneAugusto Cezar MontelliAlessandro Lia MondelliEduardo Bagagli
Credits/Source: BMC Research Notes 2010, 3:1
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