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Author Topic: Artificial kidneys  (Read 821 times)
jambo101
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« on: April 11, 2019, 03:54:49 PM »

 Was sitting in dialysis chair on Wednesday and tapping the artificial kidney my blood was going into on the Fresnius machine I asked the nurse when an artificial kidney will be manufactured and available for general implant, she said not for a while and that they wont be manufactured but rather grown in the perverbial test tube. Any one have any idea how far off this technology is?
Thanks
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Jim
Michael Murphy
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« Reply #1 on: April 11, 2019, 06:47:19 PM »

Just looked at UCSF (University  0f California San Francisco) ariificial kidney web site and they are posting that some time in 2021 they will be done clinical trials.
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jambo101
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« Reply #2 on: April 12, 2019, 11:26:45 AM »

 I wonder if the criteria to get one will be as estensive as transplant qualifications are now.
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rcjordan
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« Reply #3 on: April 12, 2019, 03:15:30 PM »

I think home machine users will see recycled dialysate first.  That will at least cut down on the massive weight, handling, & storage issue.

http://awak.com/product/
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Coastal US, NE North Carolina
2018 right nephrectomy - cancer. Left kidney not filtering, start hemo. After 3 months, start Nxstage home hemo
Alexysis
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« Reply #4 on: April 13, 2019, 07:03:39 AM »

That AWAK site is really short on specifics. Makes me wonder if it's truly legitimate.

As for an implanted artificial kidney, I'd be happy with something that would just reduce the time needed for dialysis to only once a week or so.
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rcjordan
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« Reply #5 on: April 13, 2019, 01:57:27 PM »

>legitimate

I had the same concerns. Apparently, they are legit

FDA grants breakthrough designation for AWAK’s Peritoneal Dialysis device | MobiHealthNews
https://www.mobihealthnews.com/content/fda-grants-breakthrough-designation-awak%E2%80%99s-peritoneal-dialysis-device
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Coastal US, NE North Carolina
2018 right nephrectomy - cancer. Left kidney not filtering, start hemo. After 3 months, start Nxstage home hemo
rcjordan
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« Reply #6 on: April 13, 2019, 02:02:57 PM »

<added>

As for HD, the Dutch Kidney Foundation started working with AWAK back in 2014.  Take a look at this cycler. The dialysate recycler is that little canister on the right.

Portable Artificial Kidney by Dutch Kidney Foundation on Vimeo
https://vimeo.com/307707561
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Coastal US, NE North Carolina
2018 right nephrectomy - cancer. Left kidney not filtering, start hemo. After 3 months, start Nxstage home hemo
Marilee
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« Reply #7 on: April 20, 2019, 12:38:45 PM »

Just wanted to post a link to the Artificial Kidney Facebook page... They provide updates from time to time there.
https://www.facebook.com/ArtificialKidney/?eid=ARAno5sQgRY7MRIz-fNS-xgPueCN5bwVSoTfl6IEkvU7G6yF_9373O9NR8l7M7vGHes48K3LX-FRPakC
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As my hubby would say, "Don't let what you can't do get in the way of what you can."
Riki
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« Reply #8 on: May 11, 2019, 11:38:57 PM »

Just looked at UCSF (University  0f California San Francisco) ariificial kidney web site and they are posting that some time in 2021 they will be done clinical trials.

I'm waiting on this one, myself.  I'm thinking it will be my best bet to getting off dialysis.

I wonder if the criteria to get one will be as estensive as transplant qualifications are now.

From what I understand, the criteria will be similar to transplant, as the surgery is similar to transplant.  Your body has to be able to handle the surgery or there's no real point.
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Dialysis - Feb 1991-Oct 1992
transplant - Oct 1, 1992- Apr 2001
dialysis - April 2001-May 2001
transplant - May 22, 2001- May 2004
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Marilee
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« Reply #9 on: May 12, 2019, 06:08:43 AM »

From what I've read about the "qualifications" for surgery, a person still has to be able to handle surgery in general (anesthesia, healing time) but there's no immune system response to the artificial kidney being present, and that's so great: No immune-suppressing drugs to take, no rejection to the kidney cells in the unit because they are kept isolated from the blood cells by the main filter. That's amazing to me.

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As my hubby would say, "Don't let what you can't do get in the way of what you can."
GA_DAWG
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« Reply #10 on: May 12, 2019, 09:29:06 AM »

It would seem as though we should be approaching a time when they could take cells from a person's own kidney, and grow a replacement which would alsso seem to alleviate the need for anti-rejection drugs since it would be from the person's own kidney.
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cassandra
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« Reply #11 on: May 12, 2019, 09:52:10 AM »

From what I've read about the "qualifications" for surgery, a person still has to be able to handle surgery in general (anesthesia, healing time) but there's no immune system response to the artificial kidney being present, and that's so great: No immune-suppressing drugs to take, no rejection to the kidney cells in the unit because they are kept isolated from the blood cells by the main filter. That's amazing to me.




And that’s what’s keeping me hopeful for one day not needing D. I really have to start changing my mindset though. I’m really trying to stay alive (as in: not dead) for my ‘term life insurance to pay out. That’s 21’ Sept 2021 and wouldn’t it be amazing to be ‘good enough’ for one of them beauties  :yahoo;


I’m consulting with my crystals right now :angel;
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I started out with nothing and I still have most of it left

1983 high proteinloss in urine, chemo, stroke,coma, dialysis
1984 double nephrectomy
1985 transplant from dad
1998 lost dads kidney, start PD
2003 peritineum burst, back to hemo
2012 start Nxstage home hemo
       still on waitinglist, still ok I think
Marilee
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« Reply #12 on: May 12, 2019, 11:15:26 AM »

Oh, my gosh, Cassandra, I totally understand what you mean about the difference between staying alive versus staying 'not dead'. It would be amazing that when the time comes, you, my hubby and all the candidates here can find a way to benefit. It's not a perfect solution (still gotta deal with the anemia/vitamin D stuff separately and it can't do as much filtering as a pair of good'ns) but it beats sporadic dialysis and elevates a person from Stage 5 to Stage 4 - and I look back fondly at Stage 4 now.
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As my hubby would say, "Don't let what you can't do get in the way of what you can."
Alexysis
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« Reply #13 on: May 16, 2019, 02:33:59 PM »

It would seem as though we should be approaching a time when they could take cells from a person's own kidney, and grow a replacement which would alsso seem to alleviate the need for anti-rejection drugs since it would be from the person's own kidney.

For those of us with polycystic kidneys, growing a new crappy kidney is hardly what we need. But, as to the 'artificial kidney', I'll believe it when I see it. Over the last 30 years (since my mother had HER kidneys fail), doctors have consistently said that we were "5 years away from a cure"........
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iolaire
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« Reply #14 on: May 17, 2019, 05:20:06 AM »

But, as to the 'artificial kidney', I'll believe it when I see it. Over the last 30 years (since my mother had HER kidneys fail), doctors have consistently said that we were "5 years away from a cure"........
This is my worry, people seem to get excited about the 'artificial kidney,' but it takes very long to get technology to market, especially something so complex that would have to be integrated into the body.  Luckily we have the various dialysis methods that serve today as an 'artificial kidney'.
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Transplant July 2017 from out of state deceased donor, waited three weeks the creatine to fall into expected range, dialysis December 2013 - July 2017.

Well on dialysis I traveled a lot and posted about international trips in the Dialysis: Traveling Tips and Stories section.
cassandra
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« Reply #15 on: May 17, 2019, 07:53:44 AM »

But, as to the 'artificial kidney', I'll believe it when I see it. Over the last 30 years (since my mother had HER kidneys fail), doctors have consistently said that we were "5 years away from a cure"........
This is my worry, people seem to get excited about the 'artificial kidney,' but it takes very long to get technology to market, especially something so complex that would have to be integrated into the body.  Luckily we have the various dialysis methods that serve today as an 'artificial kidney'.


I don’t think people really get excited about it. When I started HD in the 80’s the machine didn’t used to reheat the blood. Your body was the heater. It was very, very cold. You dialysed for 7 hours 2 times a week. And now we have things like Nxstage, APD, transplants which can last a very long time (when I received my dad’s kidney the max was 10 yrs) etc. It’s not really getting excited, it’s just that: who knows? Might as well think positively, crap will happen anyway 😜
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I started out with nothing and I still have most of it left

1983 high proteinloss in urine, chemo, stroke,coma, dialysis
1984 double nephrectomy
1985 transplant from dad
1998 lost dads kidney, start PD
2003 peritineum burst, back to hemo
2012 start Nxstage home hemo
       still on waitinglist, still ok I think
Michael Murphy
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« Reply #16 on: May 17, 2019, 04:58:16 PM »

If memory serves me they took the prototype and used the components to construct wearable artificial kidneys and put them on a number of patients.  The results were spectacular no fluid limits, no dietary restrictions.
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cassandra
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« Reply #17 on: May 17, 2019, 11:34:24 PM »

There's also developments fróm the Kidney Project being used in development of D-filters.
So shorter D sessions could be poss  ;D
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I started out with nothing and I still have most of it left

1983 high proteinloss in urine, chemo, stroke,coma, dialysis
1984 double nephrectomy
1985 transplant from dad
1998 lost dads kidney, start PD
2003 peritineum burst, back to hemo
2012 start Nxstage home hemo
       still on waitinglist, still ok I think
jambo101
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« Reply #18 on: May 18, 2019, 10:16:26 AM »

If memory serves me they took the prototype and used the components to construct wearable artificial kidneys and put them on a number of patients.  The results were spectacular no fluid limits, no dietary restrictions.
Ok sounds great but where are these products and how come im not being given the option of using such a device. ???
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Jim
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« Reply #19 on: May 24, 2019, 08:08:01 AM »

There's also developments fróm the Kidney Project being used in development of D-filters.
So shorter D sessions could be poss  ;D

I would take that, if it was all I could get.
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Dialysis - Feb 1991-Oct 1992
transplant - Oct 1, 1992- Apr 2001
dialysis - April 2001-May 2001
transplant - May 22, 2001- May 2004
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Michael Murphy
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« Reply #20 on: May 24, 2019, 02:21:42 PM »

The test was conducted with volunteers,  they needed to be canulated and attached to the prototype devices.  Since it was experimental they were escorted by medical personnel. 
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