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Dialysis Discussion => Dialysis: Transplant Discussion => Topic started by: draven on August 13, 2009, 09:31:58 AM

Title: anyone heard of certican
Post by: draven on August 13, 2009, 09:31:58 AM

Hi guys

some of you know i have been having issues with creatinine lately. its still up quite a bit, so doc has decided to switch me from
prograf to something called certican. anyone heard of it. know of side effects. it seems to be new on the market..


any info would be appreciated

thanks once again
:)

Title: Re: anyone heard of certican
Post by: okarol on August 13, 2009, 10:02:18 AM

From Wikipedia, the free encyclopedia

Everolimus

Everolimus (RAD-001) (marketed by Novartis under the tradenames Certican (transplantation) and Afinitor (oncology)) is a derivative of Rapamycin (sirolimus) (the structure can be written as 42-O-(2-hydroxyethyl)rapamycin), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants.

I can't find much more about it here's a little more info:

In  two large studies involving kidney transplant patients, Certican® worked as well as CellCept® in preventing acute rejection.  In studies involving heart transplant patients, acute rejection rates were lower in patients who received Certican® compared to those patients who received azathioprine.

Side effects commonly seen with Certican® occured with higher doses and were reversible when the dose was decreased. These were a decrease in platelets and an increase in cholesterol and triglycerides.  Patients will need to have blood levels of Certican® checked on a regular basis.